Eosinophilic granulomatosis with polyangiitis,asthma as the first symptom,and subsequent Loeffler endocarditis:A case report  

作　　者：Jia-Ling He Xing-Yu Liu Yi Zhang Li Niu Xin-Lin Li Xing-Yu Xie Yang-Ting Kang Lan-Qing Yang Zheng-Yang Cai Hui Long Guang-Fei Ye Jun-Xin Zou 

机构地区：[1]Department of Emergency,Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China [2]Department of Orthopedic Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China [3]Department of Internal Cardiovascular Medicine,Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China [4]Department of Medical Cosmetology,Beijing Puxiang Traditional Chinese Medicine Hospital,Beijing 100080,China [5]College of Pediatrics,Guizhou Medical University,Guiyang 550001,Guizhou Province,China [6]Department of Internal Cardiovascular Medicine,People’s Hospital of Baiyun District,Guiyang 550014,Guizhou Province,China [7]Department of Orthopedic Surgery,Hospital of Guizhou Panjiang Coal Power Group Limited Liability Company,Liupanshui 553537,Guizhou Province,China [8]Department of Imaging,Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2023年第27期6523-6530,共8页世界临床病例杂志

基　　金：Supported by the 2020 National Natural Science Foundation Cultivation Project of Guizhou Medical University Affiliated Hospital,No.gyfynsfc[2020]-14.

摘　　要：BACKGROUND Eosinophilic granulomatosis with polyangiitis(EGPA),formerly known as Churg-Strauss syndrome,is a rare form of anti-neutrophil cytoplasmic antibodyassociated vasculitis characterized by asthma,vasculitis,and eosinophilia.CASE SUMMARY We report an atypical case of EGPA in a 20-year-old female patient.Unlike previously reported cases of EGPA,this patient’s initial symptom was asthma associated with a respiratory infection.This was followed by Loeffler endocarditis and cardiac insufficiency.She received treatment with methylprednisolone sodium succinate,low molecular weight heparin,recombinant human brain natriuretic peptide,furosemide,cefoperazone sodium/sulbactam sodium,and acyclovir.Despite prophylactic anticoagulation,she developed a large right ventricular thrombus.EGPA diagnosis was confirmed based on ancillary test results and specialty consultations.Subsequent treatment included mycophenolate mofetil.Her overall condition improved significantly after treatment,as evidenced by decreased peripheral blood eosinophils and cardiac markers.She was discharged after 17 d.Her most recent follow-up showed normal peripheral blood eosinophil levels,restored cardiac function,and a reduced cardiac mural thrombus size.CONCLUSION This case illustrates the swift progression of EGPA and underscores the significance of early detection and immediate intervention to ensure a favorable prognosis.

关 键 词：Churg-Strauss syndrome Anti-neutrophil cytoplasmic antibody-associated vasculitis EOSINOPHILIA Loeffler endocarditis ASTHMA Case report 

分 类 号：R542.22[医药卫生—心血管疾病]