Treg在1型糖尿病肾病中的作用  

Role of Treg in type 1 diabetic nephropathy

作　　者：杨智雄(综述) 张危[1] 惠丹 董艳 陈卫文(审校) YANG Zhixiong;ZHANG Wei;HUI Dan;DONG Yan;CHEN Weiwen(Department of Endocrinology and Metabolism,Affiliated Qujing Hospital of Kunming Medical University,Qujing,Yunnan 655500,China;Department of Endocrinology and Metabolism,Qujing Second People′s Hospital,Qujing,Yunnan 655500,China)

机构地区：[1]昆明医科大学附属曲靖医院内分泌代谢科,云南曲靖655000 [2]曲靖市第二人民医院内分泌代谢科,云南曲靖655000

出　　处：《现代医药卫生》2023年第18期3157-3161,共5页Journal of Modern Medicine & Health

基　　金：云南省卫生健康委员会医学后备人才培养计划项目(H-2019032)。

摘　　要：糖尿病肾病(DN)是由糖尿病(DM)所致的慢性肾脏病,是常见的DM微血管病变,常出现高血压、水肿、大量蛋白尿等症状,常合并有DM视网膜病变。近年来,许多研究证据表明,免疫细胞介导的慢性炎症反应在DN的发生发展过程中起重要作用。其中T淋巴细胞与DN的病理损伤过程密切相关。调节性T细胞(Treg)是T淋巴细胞一类亚群,是维持机体免疫耐受的关键介质,可能为DN的免疫损伤提供保护。Treg可能成为该疾病新的治疗靶点。Diabetic nephropathy is a chronic kidney disease caused by diabetes mellitus(DM).It is a common diabetic microangiopathy with symptoms such as hypertension,edema,and massive proteinuria,and is often accompanied by diabetic retinopathy.In recent years,many studies have shown that immune cell-mediated chronic inflammatory response plays an important role in the occurrence and development of diabetic nephropathy.T lymphocytes are closely related to the pathological injury process of DN.Regulatory T cells(Treg),a subgroup of T lymphocytes,play a key role in maintaining immune tolerance of the body and may provide protection against immune damage in diabetic nephropathy.Treg may become a new therapeutic target for this disease.

关 键 词：1型糖尿病 糖尿病肾病 TREG细胞 

分 类 号：R587.1[医药卫生—内分泌] R587.2[医药卫生—内科学]