H_(2)O_(2) actuated molybdenum oxide nanodots:Multi-enzyme-like activities,leverage of Fenton reaction,and dual-mode sensitive detection of alendronate sodium  

作　　者：Siqi Wang Yao Jin Wenhui Ai Xiufeng Wang Zhiqing Zhang Ting Zhou Guodong Zhang Fang Wang 

机构地区：[1]Department of Chemistry,College of Chemistry and Chemical Engineering,China University of Petroleum(East China),Qingdao 266580,China

出　　处：《Nano Research》2023年第10期12106-12115,共10页纳米研究（英文版）

基　　金：National Natural Science Foundation of China(No.21603276);Fundamental Research Funds for the Central Universities(Nos.19CX02060A and 22CX03024A);the Natural Science Foundation of Shandong Province(No.ZR2022MB148).

摘　　要：Unexpected benefits to the catalytic performance of materials often originate from the presence of surface defects.Here,novel Dpenicillamine modified molybdenum oxide nanodots,with abundant oxygen vacancy defects,were fabrication by a mild,simple,and cost-effective method.Ultraviolet–visible(UV–Vis)absorption spectra analysis showed that the nanodots had peroxidaselike and catalase-like activities.The reactive oxygen species were probed by electronic paramagnetic resonance technique and spectroscopic methods,demonstrating that the nanodots also had oxidase-like activity.Interestingly,the peroxidase-like activity of nanodots was synergistically enhanced in the presence of ferrous ions or ferric ions.Remarkably,less than nanomolar levels of ferrous ions were required to display this phenomenon,meaning Fenton reagent acted as leverage.Based on this,a sensitive colorimetric and fluorescent dual-mode sensor for alendronate sodium was developed.The linear ranges for colorimetric and fluorescence analysis were 0.2–2.5 and 0.2–2.0μM,with detection limits of 31.21 and 71.84 nM,correspondingly.The method has a simple large-scale material preparation process with higher sensitivity and shorter reaction time,which can inspire and enlighten the design of nanozyme sensors.

关 键 词：nanozyme molybdenum oxide Fenton reaction alendronate sodium multi-enzyme-like activities 

分 类 号：O64[理学—物理化学]