铜催化的二醇类化合物对映选择性去对称化反应研究进展  

Research Progress on Copper-Catalyzed Enantioselective Desymmetrization of Diols

作　　者：鱼章龙 李忠良 杨昌江 顾强帅 刘心元 Yu Zhanglong;Li Zhongliang;Yang Changjiang;Gu Qiangshuai;Liu Xinyuan(Department of Chemistry and Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen 518055;Academy for Advanced Interdisciplinary Studies and Department of Chemistry,Southern University of Science and Technology,Shenzhen 518055;Department of Chemistry,School of Sciences,Great Bay University,Dongguan 523000)

机构地区：[1]南方科技大学化学系深圳格拉布斯研究院,深圳518055 [2]南方科技大学化学系前沿与交叉科学研究院,深圳518055 [3]大湾区大学理学院化学系,东莞523000

出　　处：《化学学报》2023年第8期955-966,共12页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.22025103,92256301,21831002,22101122,22001109,22271133,22201127);国家重点研发计划(Nos.2021YFF0701604,2021YFF0701704);深圳市科技计划(Nos.KQTD20210811090112004,JCYJ20220530115409020)资助。

摘　　要：二醇类化合物的对映选择性去对称化反应是合成复杂手性醇类化合物的重要方法,在药物化学、全合成和材料科学等学科中有着广阔的应用前景.铜催化剂相较于其他贵金属催化剂而言更加廉价易得,而且在反应中有着丰富的价态变化,因而近年来利用铜催化的策略实现二醇类化合物对映选择性去对称化的研究发展迅速.本综述依据二醇类化合物(内消旋二醇和前手性二醇)和反应类型的不同对该领域的研究进展进行归纳总结,并对未来发展做了简要展望.Enantioselective desymmetrization of diols is an important method for the synthesis of complex enantioenriched alcohols,which has broad application prospects in medicinal chemistry,total synthesis,and materials science.In recent years,the use of copper catalysis to achieve diols’enantioselective desymmetrization has progressed rapidly because copper is inexpensive and readily available compared with other noble metal catalysts.Besides,copper undergoes a two-electron or single-electron transfer process in the catalytic cycle,and the rich oxidation states of copper provides the opportunity to solve some challenging problems.This review summarizes the research progress in this field according to the types of diols(meso diol and prochiral diol)and reactions together with a brief perspective.

关 键 词：铜催化 去对称化 二醇类化合物 不对称催化 

分 类 号：O621.251[理学—有机化学]