人血清白蛋白结合型分子探针在核医学诊疗中的研究进展  

Research progress of human serum albumin binding molecular probe in diagnosis and treatment of nuclear medicine

作　　者：韩彦江[1] 王猛[1] 智生芳 徐万帮[3] Han Yanjiang;Wang Meng;Zhi Shengfang;Xu Wanbang(GDMPA Key Laboratory for Quality Control and Evaluation of Radiopharmaceuticals,Department of Nuclear Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Nuclear Medicine,the Tenth Affiliated Hospital of Southern Medical University(Dongguan People's Hospital),Dongguan 523059,China;NMPA Key Laboratory for Rapid Testing Technology of Drug,Guangdong Institute for Drug Control,Guangzhou 510663,China)

机构地区：[1]南方医科大学南方医院核医学科,广东省药品监督管理局放射性药物质量控制与评价重点实验室,广州510515 [2]南方医科大学第十附属医院(东莞市人民医院)核医学科,东莞523059 [3]广东省药品检验所,国家药品监督管理局药品快速检验技术重点实验室,广州510663

出　　处：《国际放射医学核医学杂志》2023年第8期496-502,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：东莞市社会发展科技项目(20231800935972);南方医院院长基金(2020L002)。

摘　　要：人血清白蛋白(HSA)是一种多功能蛋白质,能结合和运输多种内源性和外源性化合物,也可作为药物载体用于肿瘤的靶向给药。通过在药物分子中添加功能性化学基团可实现药物与HSA的结合,增加药物在血液中的循环时间,同时不会显著影响药物的生物活性,这种方法可以提高放射性治疗药物在肿瘤部位的浓集程度并延长浓集时间,改善其靶向治疗的效果。HSA结合型分子探针还可用于心脏功能和血管通透性评价以及淋巴显像。笔者综述了近年来各种HSA结合型分子探针在核医学诊疗中的研究进展。Human serum albumin(HSA)is a multi-functional protein,which is able to bind and transport a variety of endogenous and exogenous compounds.HSA can be used as a drug carrier in the targeted delivery of cancer drug therapy.To bind to HSA,a large variety of strategies has been developed through adding functional chemical groups to the drug molecule,thus changing the pharmacokinetics,increasing the circulation time of the drug in the blood without significantly affecting its biological activity.This strategy can increase the concentration and prolong the time of radiotherapeutic drugs at the tumor site and improve the effect of radionuclide targeted therapy.Drugs binding to HSA has been exploited to evaluate cardiac function,vascular permeability,and lymphography.In this review article,the recent developments of various ligands binding to HSA in the diagnosis and treatment of nuclear medicine are reviewed.

关 键 词：血清白蛋白 人 核医学 分子探针 

分 类 号：R817[医药卫生—影像医学与核医学]