多重即时检测技术在传染病诊断中的研究进展  

Research progress on multiplexed point-of-care testing technology for the diagnosis of infectious diseases

作　　者：陈福民 李慧敏 解艺 修乐山 胡沁沁 殷堃 郭晓奎[1] Chen Fumin;Li Huimin;Xie Yi;Xiu Leshan;Hu Qinqin;Yin Kun;Guo Xiaokui(School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院-国家热带病研究中心全球健康学院,上海200025

出　　处：《中华检验医学杂志》2023年第9期964-970,共7页Chinese Journal of Laboratory Medicine

基　　金：美国中华医学基金会“全健康:从领域到政策”项目(20-365);国家自然科学基金(22104090)。

摘　　要：快速、准确的诊断技术能有效防控传染病传播,遏制疫情发展。多重即时检测(x-POCT)技术可有效避免单一目标检测的局限性,实现多种传染性疾病的快速筛查和及时防控。该文总结x-POCT在传染性疾病及其病原体诊断中的应用,包括针对不同靶标的x-POCT检测方法,重点阐述了微流控芯片、纸基与微滴体系等设备平台,并探讨了本领域现存挑战与未来发展方向,以及x-POCT在基于"全健康"理念的高效传染病防控网络中的应用前景。Accurate and rapid diagnosis of infectious diseases can effectively prevent their spread and promptly curb the epidemic hazards.Multiplexed point-of-care testing(x-POCT)technology can effectively avoid misdiagnosis caused by the detection of one single target and achieve rapid screening and timely control of multiple infectious diseases.Research progress and the latest applications of x-POCT including x-POCT assay methods for different targets in the diagnosis of infectious diseases and their pathogens are summarized in this review.The paper-based,microfluidic chip-based,and microdroplet-based device platforms of x-POCT,and eventually the challenges and future perspectives of x-POCT,especially progress on the effective infectious disease surveillance network establishment under One Health concept are highlighted.

关 键 词：传染病 即时检测 诊断 

分 类 号：R51[医药卫生—内科学]