血浆微颗粒在静脉血栓凝血机制中的研究进展  

Progress in the study of plasma microparticles in the coagulation mechanism of venous thromboembolism

作　　者：臧新伟 吴俊 Zang Xinwei;Wu Jun(Department of Clinical Laboratory,Peking University Fourth School of Clinical Medicine,Beijing 100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院,医学检验中心,北京100035

出　　处：《中华检验医学杂志》2023年第9期977-982,共6页Chinese Journal of Laboratory Medicine

摘　　要：许多静脉血栓栓塞(VTE)的临床病例诱因不明,且缺乏典型的临床症状,因此急需开发可靠的生物标志物辅助VTE的预测和诊断等。微颗粒(MP)是由活化、损伤或凋亡细胞产生的细胞外囊泡,携带多种生物活性物质,具有广泛的生理功能并参与多种疾病的病理进程。近年来随着研究手段的进步,MP对凝血过程复杂的调节作用被逐渐揭示。MP参与了多种临床VTE相关疾病的病理进程,因此在提示VTE风险和辅助VTE诊断方面拥有的潜在的应用价值,对MP进行系统的研究对于临床VTE相关疾病的诊治具有重要意义。Many clinical cases of venous thromboembolism(venous thromboembolism,VTE)have unknown causative factors and lack typical clinical symptoms.Therefore,there is an urgent need to develop reliable biomarkers for prediction,diagnosis and therapeutic monitoring of VTE at an early stage.Microparticles(MP)are phospholipid bilayer vesicles produced by activated,damaged,or apoptotic cells.They carry a variety of biologically active substances,such as proteins,nucleic acids,and lipids,which have a wide range of physiological functions and participate in the pathology process of certain diseases.In recent years,the role of MP in the occurrence and development of VTE has been continuously revealed.With the advancement of research technology,the complex regulatory role of MP on the coagulation process has been gradually discovered.MP is involved in the pathological process of various clinical VTE-related diseases,and has potential applications in indicating the risk of VTE and aiding in the diagnosis and treatment of VTE.The systematic study of MP is important for the diagnosis and treatment of clinical VTE related diseases.

关 键 词：微颗粒 静脉血栓栓塞 临床应用 

分 类 号：R543.6[医药卫生—心血管疾病]