Nrf2对睾丸微环境的影响及其在男性疾病中的研究进展  

Effect of Nrf2 on the testicular microenvironment and its research progress in male diseases

作　　者：吴悔 宁港 李波男 周兴[1] Hui Wu;Gang Ning;Bonan Li;Xing Zhou(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;College of Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学中西医结合学院,湖南长沙410208

出　　处：《Journal of Chinese Pharmaceutical Sciences》2023年第7期513-526,共14页中国药学（英文版）

基　　金：The National Natural Science Foundation of China(Grant No.82074444);Hunan Natural Science Foundation Outstanding Youth Fund project(Grant No.2023JJ10032);the Key Projects of Hunan Provincial Department of Education(Grant No.20A368);Changsha Science and Technology Plan Project-Changsha Outstanding Innovative Youth Training Program(Grant No.kq1802015)。

摘　　要：氧化应激是机体活性氧产生与抗氧化之间的失衡,参与临床诸多疾病的发生及进展过程。Nrf2是机体中和细胞内活性氧产生和恢复氧化还原平衡的主要调节因子,对机体产生广泛的调控作用。Nrf2通过调控睾丸微环境改善间质细胞、支持细胞、生精细胞等氧化损伤,影响睾酮合成,保护男性生殖健康,对男性迟发性性腺功能减退症和男性不育症的发病具有重要调控作用。此外,Nrf2还参与良性前列腺增生、前列腺癌、前列腺炎、勃起功能障碍、精索静脉曲张等诸多男性疾病的发生。Nrf2有望成为男性疾病预防与治疗的重要靶点之一,具有广阔的临床应用前景。Oxidative stress(OS)is an imbalanced state between the production of reactive oxygen species(ROS)and antioxidation,and plays a crucial role in the development and progression of various diseases.Nrf2,a major regulator of ROS production and restoration of redox balance,exerts significant regulatory effects on the body and cells.For example,by regulating the testis microenvironment,Nrf2 can improve oxidative damage to Leydig,Sertoli,and spermatogenic cells,thus affecting testosterone synthesis and protecting male reproductive health.Moreover,Nrf2 is crucial in regulating late-onset hypogonadism in males and male infertility.Nrf2 is also involved in the pathogenesis of many other male diseases,such as benign prostatic hyperplasia,prostate cancer,prostatitis,erectile dysfunction,and varicocele.Therefore,Nrf2 could be a promising target for treating and preventing male diseases,and it holds great potential in clinical practice.

关 键 词：NRF2 睾丸微环境 男性疾病 研究进展 

分 类 号：R963[医药卫生—微生物与生化药学]