海洛因使用障碍者大脑低频振幅动态性的静息态功能MRI研究  

Alterations of dynamic amplitude of low frequency fluctuation in patients with heroin use disorder:a resting-state functional MRI study

作　　者：陈佳杰 李依峣 黄鹏 李永斌 金龙 李玮 王玮 李强 CHEN Jiajie;LI Yiyao;HUANG Peng;LI Yongbin;JIN Long;LI Wei;WANG Wei;LI Qiang(Department of Radiology,Tangdu Hospital,the Air Force Military Medical University,Xi'an 710038,China;Team 6,Group 2,Cadet Team,School of Basic Medicine,the Air Force Military Medical Umiversity,Xi'an 710032,China;Department of Imaging,Xi'an First Hospital,Xi'an 710002,China)

机构地区：[1]空军军医大学唐都医院放射科,陕西西安710038 [2]空军军医大学基础医学院学员队二大队六队,陕西西安710032 [3]西安市第一医院影像科,陕西西安710002

出　　处：《实用放射学杂志》2023年第8期1213-1216,共4页Journal of Practical Radiology

基　　金：陕西省自然科学基础研究-青年项目(2020JQ-883);陕西省教育厅2020年一般自然专项科学研究计划项目(20JK0903);空军军医大学科技发展基金项目(2022XC053)。

摘　　要：目的探讨海洛因使用障碍(HUD)者大脑神经活动动态特征的潜在变化特征。方法招募未经治疗的HUD者31例(HUD组)与年龄、受教育程度、吸烟史相匹配的健康对照(HC)34例(HC组),收集人口学与影像学数据。利用滑动时间窗技术进行动态低频振幅(dALFF)分析,比较2组间差异脑区,并与吸食时间进行相关性分析。结果与HC组相比,HUD组右侧岛叶、壳核与尾状核dALFF值显著降低,右侧尾状核降低的dALFF值与海洛因吸食时间呈负相关性。结论HUD多巴胺相关脑区的dALFF值降低可能与奖赏和认知功能整合障碍有关。Objective e To explore the alterations of the dynamic characteristics of brain neural activity in patients with heroin use disorder(HUD).Methods A total of 31 untreated HUD patients(HUD group)and 34 healthy control(HC)(HC group)were recruited and collected demographic and imaging data.The HUD and HC groups were well matched with age,education and smoking history.The dynamic amplitude of low frequency fluctuations(dALFF)was analyzed by sliding window technique.The significant differences of brain regions between the two groups were compared.The Pearson correlation was further performed to demonstrate the relationships between significantly different brain regions and drug use time.Results The dALFF values of the right insula,putamen and caudate nucleus of HUD group were significantly lower than those of HC group.The dALFF value of the right caudate nucleus was negatively correlated with the duration of heroin use in HUD group.Conclusion The decreased dALFF value of dopamine-related brain regions in patients with HUD may be related to the integration impairment of reward and cognitive functions.

关 键 词：动态低频振幅 海洛因 成瘾 尾状核 磁共振成像 

分 类 号：R971.1[医药卫生—药品] R651[医药卫生—药学] R445.2