枫香脂中1个新的肉桂酸酯衍生物  

A new cinnamic acid ester derivative from Liquidambaris Resina

作　　者：许少英 肖琴文 赵苏敏 管一键 袁燎恒 朱瑶 王朝杰 严鹏程 董建勇 XU Shao-ying;XIAO Qin-wen;ZHAO Su-min;GUAN Yi-jian;YUAN Liao-heng;ZHU Yao;WANG Chao-jie;YAN Peng-cheng;DONG Jian-yong(School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学药学院,浙江温州325035

出　　处：《中国中药杂志》2023年第15期4130-4136,共7页China Journal of Chinese Materia Medica

摘　　要：运用硅胶柱色谱、薄层色谱等分离方法从枫香脂中分离得到12个化合物,根据波谱数据、ECD和理化性质鉴定其结构,分别为(2′R,3′R)-2′,3′-dihydroxy-hydrocinnamyl-(E)-cinnamate(1)、(E)-cinnamyl-(E)-cinnamate(2)、cinnamic acid(3)、28-norlup-20(29)-en-3-one-17β-hydroperoxide(4)、高根二醇(5)、13β,28-epoxy-30-hydroxyolean-1-en-3-one(6)、(3β)-olean-12-ene-3,23-diol(7)、2α,3α-dihydroxy-olean-12-en-28-oic acid(8)、28-hydroxyolean-12-en-3-one(9)、3-epi-oleanolic acid(10)、3-oxo-oleanolic acid(11)、hederagenin(12)。其中化合物1是1个新的肉桂酸酯衍生物,化合物2~4、6~8、12为首次从枫香脂中分离得到。化合物4、5、10、12具有抑制人脐静脉内皮细胞(HUVEC)增殖的作用,其IC_(50)分别为(17.43±2.17)、(35.32±0.61)、(27.50±0.80)、(46.30±0.30)μmol·L^(-1)。Twelve compounds were isolated from Liquidambaris Resina by silica gel column chromatography and thin layer chromatography.Their structures were identified on the basis of spectral data,electron capture detector data,and physicochemical properties as(2′R,3′R)-2′,3′-dihydroxy-hydrocinnamyl-(E)-cinnamate(1),(E)-cinnamyl-(E)-cinnamate(2),cinnamic acid(3),28-norlup-20(29)-en-3-one-17β-hydroperoxide(4),erythrodiol(5),13β,28-epoxy-30-hydroxyolean-1-en-3-one(6),(3β)-olean-12-ene-3,23-diol(7),2α,3α-dihydroxy-olean-12-en-28-oic acid(8),28-hydroxyolean-12-en-3-one(9),3-epi-oleanolic acid(10),3-oxo-oleanolic acid(11),and hederagenin(12).Compound 1 was a new cinnamic acid ester derivative and compounds 2-4,6-8,and 12 were isolated from Liquidambaris Resina for the first time.Compounds 4,5,10,and 12 exerted inhibitory effects on the proliferation of human umbilical vein endothelial cells(HUVEC)with the IC_(50)values of(17.43±2.17),(35.32±0.61),(27.50±0.80),and(46.30±0.30)μmol·L^(-1),respectively.

关 键 词：枫香树 枫香脂 肉桂酸酯 化学成分 

分 类 号：R284.1[医药卫生—中药学]