DOTA-三叔丁酯-乙酯的碱性与酸性水解  

DOTA-t-Bu-m-Et ester was hydrolyzed under alkaline and acidic conditions

作　　者：张元红 王艳芳[1] 王日为[1] 张丽丽[1] 姜林[1] 万福贤[1] ZHANG Yuanhong;WANG Yanfang;WANG Riwei;ZHANG Lili;JIANG Lin;WAN Fuxian(College of Chemistry and Material Science,Shandong Agricultural University,Taian 271018,China)

机构地区：[1]山东农业大学化学与材料科学学院,山东泰安271018

出　　处：《实验室科学》2023年第4期19-23,共5页Laboratory Science

基　　金：山东省自然科学基金面上项目(项目编号:ZR2020MB011);山东省高等教育本科教学改革研究项目(项目编号:M2020284);山东农业大学教学改革研究项目(项目编号:XM202046,S2021049)。

摘　　要：DOTA类大环多氨多羧配体对过渡态和镧系金属离子表现出良好的热力学稳定性和动力学惰性,因此广泛应用于磁共振成像造影剂和放射药物等领域。1-(乙氧羰甲基)-4,7,10-三(叔丁氧羰甲基)-1,4,7,10-四氮杂环十二烷中同时含有叔丁基酯和乙基酯,两种不同类型的烷基酯对酸性或碱性水解条件反应活性不一样,从而可以有针对性地合成不同的目标结构。利用这一化合物的特定结构,设计了一个面向大学高年级本科生或研究生的综合性合成实验,综合多篇文献选择并优化了适宜创新性教学实验的方法和条件。该综合型合成实验在培养学生有机化学实验基本技能的基础上,着重培养了学生的分析解决问题能力、研究探索能力和创新能力。DOTA macrocyclic polyamines polycarboxylated ligands shows high thermodynamic stability and kinetic inertness for a large number of transition states and lanthanide metal ions,so they are widely used in the fields of magnetic resonance imaging contrast agents and radiotherapeutics.1-(ethyl acetate)-4,7,10-(tert-butoxylmethyl)-1,4,7,10-tetracyclododecane contains both tert-butyl ester and ethyl ester,two types of alkyl esters have different reaction activities under acidic or basic hydrolysis conditions,so which can be choosed to synthesize different target structures under acidic or basic hydrolysis conditions.Using the specific structure of this compound,a comprehensive synthesis experiment was designed for senior undergraduates or postgraduates,and selected and optimized a suitable methods and conditions for class experiment by integrating several literatures.During the experiment,students acquired fundamental experience in organic chemistry and gained analysis skills,critical thinking,and scientific literacy.

关 键 词：有机化学实验 大环多氨多羧配体 叔丁基酯 乙基酯 水解 

分 类 号：O621.3[理学—有机化学]