Stroke-like presentation of acute toxic leukoencephalopathy due to capecitabine treatment with extensive intramyelinic edema  

作　　者：Julia Feige Fritz Klausner Johannes A.R.Pfaff Eugen Trinka Slaven Pikija Mahdi Safdarian 

机构地区：[1]Department of Neurology,Neurocritical Care and Neurorehabilitation,Centre of Cognitive Neuroscience,Christian Doppler University Hospital,Paracelsus Medical University,Salzburg,Member of EpiCARE,Salzburg,Austria [2]Department of Neuroradiology,Christian Doppler University Hospital,Paracelsus Medical University,Salzburg,Austria [3]Neuroscience Institute,Christian‐Doppler University Hospital,Paracelsus Medical University,Centre for Cognitive Neuroscience,Salzburg,Austria [4]Institute of Public Health,Medical Decision‐Making and HTA,UMIT‐Private University for Health Sciences,Medical Informatics and Technology,Hall in Tyrol,Austria

出　　处：《Chronic Diseases and Translational Medicine》2023年第3期258-262,共5页慢性疾病与转化医学（英文版）

摘　　要：1|INTRODUCTION Capecitabine is an oral prodrug of 5-fluorouracil(5-FU),which is widely used for adjuvant and neoadjuvant chemotherapy of different solid tumors,particularly breast and colorectal cancers.1 Neurotoxicity of capecitabine has been consistently reported as capecitabine-induced toxic leukoencephalopathy,which includes bilateral lesions in the corpus callosum and corticospinal tract presenting as acute or delayed central nervous system toxicity.2 This side effect requires discontinuation of chemotherapy3;however,neurological symptoms due to capecitabine are reported to be usually reversible upon drug withdrawal.

关 键 词：CAPECITABINE intramyelinic edema LEUKOENCEPHALOPATHY STROKE 

分 类 号：R969[医药卫生—药理学]