低频超声在抗感染领域的应用现状  

Application status of low-frequency ultrasound in the field of anti-infection

作　　者：闫开成 陈丽[3] 刘晓丽[4] 梁文馨 蔡芸[2] Yan Kaicheng;Chen Li;Liu Xiaoli;Liang Wenxin;Cai Yun(Medical School of Chinese PLA,Beijing 100853;Center of Medicine Clinical Research,Department of Pharmacy,Medical Supplies Center,Chinese PLA General Hospital,Beijing 100853;Department of Information,Medical Supplies Center,Chinese PLA General Hospital,Beijing 100853;Department of Dermatology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院医疗保障中心药剂科药物临床研究室,北京100853 [3]解放军总医院医疗保障中心信息科,北京100853 [4]解放军总医院第一医学中心皮肤科,北京100853

出　　处：《中国抗生素杂志》2023年第8期869-878,共10页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81770004,No.82073894);解放军总医院杰出青年科学家培养项目(No.2020-JQPY-004)。

摘　　要：抗菌药物的不合理使用,导致耐药菌感染成为影响人类健康的一大危机,虽然近些年研发了一些新型抗菌药物,但耐药趋势并未逆转,目前急需替代疗法来应对这一危机。低频超声作为一个安全且有应用前景的物理方法,在抗感染领域的应用越来越被受到重视,与抗菌药物联合应用能产生协同杀菌作用,杀菌机制包括热效应、机械效应和空化效应。本文综述了体内外低频超声联合抗菌药物在抗浮游菌和生物被膜、促进植入物药物释放和临床应用的特点,旨在对低频超声进一步研究和未来在抗感染领域的应用提供指导。The irrational use of antibiotics has led to the infection of drug-resistant bacteria,which has become a major crisis affecting human health.Although some new antibiotics have been developed in recent years,the trend of drug resistance has not reversed.At present,there is an urgent need for alternative therapy to deal with this crisis.As a safe and promising physical method,low-frequency ultrasound has attracted more and more attention in the field of anti-infection.Combined with antibiotics,it can produce synergistic bactericidal effects.The bactericidal mechanism includes thermal effects,mechanical effects and cavitation effects.This review summarizes the characteristics of low-frequency ultrasound combined with antibiotics in anti-planktonic bacteria and biofilm,promoting implant drug release and clinical application in vivo and in vitro,in order to provide guidance for the further research of lowfrequency ultrasound and its application in the field of anti-infection in the future.

关 键 词：低频超声 抗感染 空化效应 浮游菌 生物被膜 植入物 

分 类 号：R978.1[医药卫生—药品]