利用斑马鱼神经行为学毒性特征评估外源性重金属镉暴露的健康风险  

Assessing the Health Risks of Exogenous Heavy Metal Cadmium Exposure by the Neurobehavioral Toxicity Characteristics of Zebrafish

作　　者：姜丽 赵巍巍 柳莹[4] 张立秋 薛长松 JIANG Li;ZHAO Weiwei;LIU Ying;ZHANG Liqiu;XUE Changsong(Key Technology Research Center for Secondary Development of Listed Drugs,Tonghua Normal University,TonghuaJilin 134002,China;College of Pharmacy,Yanbian University,Yanji Jilin 133000,China;Changchun CustomsTechnology Center,Changchun Jilin 130001,China;Tonghua Institute For Food and Drug Control,Tonghua Jilin134001,China;Tonghua Guozhen Bufan Technology Development Co.,Ltd,Tonghua Jilin 134001,China)

机构地区：[1]通化师范学院医药学院上市中药二次开发关键技术研究中心,吉林通化134002 [2]延边大学药学院,吉林延吉133000 [3]长春海关技术中心,吉林长春130001 [4]吉林省通化市食品药品检验所,吉林通化134001 [5]通化果真不凡科技开发有限公司,吉林通化134001

出　　处：《现代畜牧科技》2023年第9期10-12,共3页Modern Animal Husbandry Science & Technology

基　　金：吉林省科技厅医药健康领域项目(20200404031YY);教育部“春晖计划”合作科研项目(202201730);科技部科技基础资源调查专项(2019FY100504);吉林省教育科学“十四五”规划项目(GH21253);大学生创新创业训练计划(国家级2022063,省级2022139);吉林省企业“科创专员”项目(216);通化海关国家参茸及参茸制品检测检验中心与通化师范学院合作项目(院企2021-02)。

摘　　要：为评估外源性重金属镉暴露对斑马鱼胚胎发育毒性和对幼鱼神经发育的影响,将受精后9 h的相同发育期斑马鱼胚胎暴露于不同浓度氯化镉中72 h后,取出置于正常水质中120 h后,评估外源性重金属镉暴露下的斑马鱼胚胎发育毒性和斑马鱼神经行为毒性。结果表明,一定剂量下,斑马鱼胚胎发育异常个体增多,表现出一定的发育毒性;幼鱼运动行为学异常,表现出一定的神经行为毒性。To evaluate the toxicity of exogenous heavy metal cadmium exposure on the embryonic development of zebrafish and its impact on the neural development of juvenile fish,post fertilization zebrafish embryos(9 hours post fertilization)were exposed to different concentrations of cadmium chloride for 72 hours.They were taken out and placed in normal water for 120 h,for evaluating the embryonic developmental toxicity and neurobehavioral toxicity of zebrafish exposed to exogenous heavy metal cadmium.The results at a certain dose showed that the number of abnormal embryonic development in zebrafish increased and exhibiting certain developmental toxicity,Juvenile fish exhibit abnormal motor behavior and exhibiting certain neurobehavioral toxicity.

关 键 词：斑马鱼 氯化镉 毒性 神经行为 

分 类 号：R966[医药卫生—药理学]