2022年四川省一起Omicron变异株感染者特征及相关因素分析  

Characteristics and related influencing factors of an epidemic caused by Omicron variant in Sichuan Province in 2022

作　　者：董爽 程秀伟[1] 周丽君[1] 肖崇堃[1] 袁珩[1] DONG Shuang;CHENG Xiuwei;ZHOU Lijun;XIAO Chongkun;YUAN Heng(Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川省疾病预防控制中心,成都610041

出　　处：《寄生虫病与感染性疾病》2023年第3期146-151,共6页Parasitoses and Infectious Diseases

基　　金：国家自然科学基金委员会面上项目(项目编号:52078423)。

摘　　要：目的分析四川省新冠Omicron变异株感染者临床严重程度分布情况,探讨不同临床严重程度的影响因素,为新冠不同临床严重程度感染者防控提供有效科学依据。方法从国家传染病报告信息管理系统导出2022年8月7日至10月10日四川省新冠报告病例个案信息,结合流调报告完善病例信息。采用SPSS 23.0软件对数据整理和分析,通过卡方检验、非条件Logistic回归等方法探讨临床严重程度及影响因素。结果四川省2022年8月7日至10月10日关联疫情共纳入患者4915例。临床诊断分型中,无症状感染者占42.64%,轻型占51.56%,普通型占5.72%,重型和危重型各占0.04%。不同年龄组主要首发症状差异均有统计学意义(P均<0.001)。多因素分析结果显示,年龄和新冠疫苗接种剂次与感染者临床严重程度有关。结论四川省新冠Omicron变异株感染者临床症状较轻,重症和危重症率低,65岁及以上和未接种新冠疫苗者的临床症状更为明显。应加强该类人群重点宣传,提高该人群的个人防护意识,65岁及以上老年人应加强新冠疫苗全程接种。Objective To analyze the distribution of clinical severity of COVID-19 Omicron variant infection in Sichuan Province,to explore the influencing factors of different clinical severity,and to provide effective scientific basis for the prevention and control of COVID-19 infection with different clinical severity.Methods The basic data of COVID-19 cases in Sichuan Province from August 7 to October 10,2022 were collected through the Chinese Disease Control and Prevention Information Management System,and the case information was improved by combining with the epidemiological investigation reports.SPSS 23.0 was used to collate and analyze the data,and the clinical severity and influencing factors were discussed through Chi-square test and unconditional Logistic regression.Results From August 7 to October 10,2022,a total of 4915 cases were enrolled into the related outbreak in Sichuan Province.Among the clinical diagnostic types,asymptomatic infections accounted for 42.64%,mild infections accounted for 51.56%,common infections accounted for 5.72%,severe and critical infections accounted for 0.04%,respectively.There were statistically significant differences in the primary symptoms among different age groups(all P<0.001).The results of multivariate analysis showed that age and COVID-19 vaccination dose were related to the clinical severity of the infected patients.Conclusions The clinical severity of COVID-19 Omicron variant infected patients in Sichuan Province was mild,and the rate of severe and critical illness was low.The clinical severity of patients over 65 years old and those who had not received COVID-19 vaccine was more obvious.It is necessary to strengthen the key publicity of such people and improve their personal protection awareness.The elderly over 65 years should strengthen the whole process of COVID-19 vaccination.

关 键 词：新冠 临床严重程度 影响因素 

分 类 号：R511[医药卫生—内科学] R181.3[医药卫生—临床医学]