三苯双脒2种用药方式治疗华支睾吸虫感染疗效分析  

Analysis on the therapeutic effect of two ways of using tribendiamidine in the treatment of clonorchis sinensis infection

作　　者：黄星炯 班贡生 陆丽艳 林世保 李玉琦 黄显泽 杨益超[2] HUANG Xingjiong;BAN Gongsheng;LU Liyan;LIN Shibao;LI Yuqi;HUANG Xianze;YANG Yichao(Wuming Center for Disease Prevention and Control,Nanning 530100,Guangxi Province,China;Guangxi Center for Disease Prevention and Control,Nanning 530000,Guangxi Province,China)

机构地区：[1]南宁市武鸣区疾病预防控制中心,南宁530100 [2]广西壮族自治区疾病预防控制中心,南宁530000

出　　处：《寄生虫病与感染性疾病》2023年第3期158-161,166,共5页Parasitoses and Infectious Diseases

基　　金：广西壮族自治区卫生健康委科研项目(项目编号:Z20201471);南宁市武鸣区科技计划项目(项目编号:20200218)。

摘　　要：目的观察三苯双脒2种不同用药方式治疗华支睾吸虫感染的疗效,为治疗华支睾吸虫感染临床用药方案选择提供科学依据。方法2020年10月至2022年8月,在广西南宁市武鸣区疾病预防控制中心寄生虫防治门诊就诊的华支睾吸虫感染者,按感染者确诊入组的时间段分层随机分为2剂次隔周服组和3剂次连服组。2剂次隔周服组使用三苯双脒2剂次顿服,单剂400 mg,第1剂次与第2剂次间相隔7 d;3剂次连服组使用三苯双脒3剂次顿服,单剂400 mg,连服3 d;均为夜间临睡前服用,服药1个月后遵嘱复诊复查,观察治疗前后虫卵数量变化及药物不良反应。采用SPSS 17.0统计软件,计数资料组间比较采用χ^(2)检验,计量资料组间均数比较采用t检验,以P<0.05为差异有统计学意义。结果2组入组治疗观察者451例,其中2剂次隔周服组216例,轻度、中度感染者分别占比87.96%(190/216)、11.11%(24/216);3剂次连服组235例,轻度、中度感染者分别占比87.66%(206/235)、11.06%(26/235)。治疗后2组总阴转率96.23%(434/451),虫卵减少率99.42%。2组间虫卵阴转率比较差异无统计学意义(χ^(2)=0.033,P=0.855)。2组内轻度和中度感染阴转率组间比较差异均无统计学意义(χ^(2)均为0.000,P均为1.000)。药物不良反应发生率5.54%(25/451),以头晕多见,症状较轻,持续时间短。结论三苯双脒治疗华支睾吸虫感染,单剂400 mg、2剂次隔周顿服及3剂次连服均取得较好的治疗效果,可在临床推广应用。Objective To observe the efficacy of tribendiamidine in the treatment of clonorchis sinensis infection,and to provide scientific basis for the selection of clinical medication for the treatment of clonorchis sinensis infection.Methods From October 2020 to August 2022,patients infected with clonorchis sinensis and treated in the Parasite Prevention and Control Clinic of Wuming Center for Disease Control and Prevention of Nanning City,were randomly divided into two groups according to the time period when the patients were diagnosed and enrolled:two-dose biweekly administration group and three-dose continuous administration group.In the two-dose biweekly administration group,tribendiamidine was given twice,with a single dose of 400 mg,and the interval between the first and second doses was 7 days.In the three-dose continuous administration group,tribendiamidine was given three times,with a single dose of 400 mg,for 3 days,and all were taken at night before going to bed.After taking the drug for one month,patients revisited and were examined as instructed to observe the changes in the number of eggs and adverse drug reactions before and after treatment.SPSS 17.0 statistical software was used.Chisquare test was used to compare count data between groups.T test was used to compare the mean of measurement data between groups.And P<0.05 was considered to be statistically significant.Results A total of 451 observers were included in the two groups,among which the two-dose biweekly administration group had 216 cases,with mild and moderate infections accounting for 87.96%(190/216)and 11.11%(24/216),respectively,and the three-dose continuous administration group had 235 cases,with mild and moderate infections accounting for 87.66%(206/235)and 11.06%(26/235),respectively.The total negative conversion rate of the two groups was 96.23%(434/451)after treatment,and the egg reduction rate was 99.42%.There was no significant difference in the conversion rate of eggs between the two groups(χ^(2)=0.033,P=0.855).There was no signific

关 键 词：华支睾吸虫 三苯双脒 用药方式 疗效 

分 类 号：R532.23[医药卫生—内科学]