自愈合咪唑盐聚离子液体/聚丙烯酸多层结构构建及抗菌性能研究  

Construction of self-healable multilayer structure and antibacterial properties study of imidazole salt based poly(ionic liquids)/poly(acrylic acid)

作　　者：熊晨崴 周鑫叠 周超[5] 张俊杰 王皓[1,2] 黄勇 XIONG Chenwei;ZHOU Xindie;ZHOU Chao;ZHANG Junjie;WANG Hao;HUANG Yong(Department of Orthopedics,The Affiliated Changzhou Second People′s Hospital of Nanjing Medical University,Changzhou 213000,China;Changzhou Medical Center,Nanjing Medical University,Changzhou 213000;Department of Graduate School,Dalian Medical University,Dalian 116000,China;Department of Orthopedics,Gonghe County Hospital of Traditional Chinese Medicine,Hainan Tibetan Autonomous Prefecture,Qinghai Province 811800,China;Institute of Biomedical Engineering and Health Sciences,Changzhou University,Changzhou 213164)

机构地区：[1]南京医科大学附属常州第二人民医院骨科,常州213000 [2]南京医科大学常州医学中心,常州213000 [3]大连医科大学研究生院,大连116000 [4]共和县中医院骨科,青海省海南藏族自治州共和县811800 [5]常州大学医学与健康工程学院,常州213164

出　　处：《生物医学工程研究》2023年第3期265-271,共7页Journal Of Biomedical Engineering Research

基　　金：常州市科技计划项目(CJ20220120)。

摘　　要：为提高生物医学设备表面涂层的抑菌稳定性,本研究使用层层自组装技术将呋喃结构的咪唑盐聚离子液体作为聚阳离子电解质层和抗菌剂,与作为聚阴离子电解质层的聚丙烯酸接枝糠胺沉积在不锈钢表面,并通过Diels-Alder环化反应,使用双马来酰亚胺聚乙二醇交联剂将聚合物层交联起来,以提高涂层的稳定性。该多层涂层性能稳定、具有自愈性,还对金黄色葡萄球菌和大肠杆菌具有持久的抗菌活性。此外,涂层成骨细胞(MC3T3-E1)具有较低的细胞毒性。该方法可对生物医疗器械表面抗感染防护提供有效策略。In order to improve the bacteriostatic stability of the surface coating of biomedical equipment,the layer-by-layer(LbL)self-assembly technique was used to deposit antibacterial furan imidazolium based poly(ionic liquids)(PILF)as cationic polyelectrolyte and antibacterial agent and poly(acrylic acid)grafting 2-furfurylamine(PAAF)as anionic polyelectrolyte on the surface of stainless steel.The polymer layers were cross-linked by bismaleimide poly(ethylene glycol)linker(MPEG)via Diels-Alder cycloaddition to enhance the stability of the coatings.The multilayer coatings not only exhibited self-healable and stable properties,but also demonstrated sustainable antibacterial activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).Furthermore,these coatings showed no toxicity effect towards seeded osteoblastic cells(MC3T3-E1).This method can provide effective strategy for the anti-infective protection of biomedical devices.

关 键 词：自愈合涂层 聚离子液体 表面抗菌 涂层稳定性 抗感染 层层自组装 

分 类 号：R318[医药卫生—生物医学工程]