Kv7通道开放剂瑞替加滨对小鼠炎症性疼痛的镇痛作用研究  

Analgesic Effects of the Kv7 Channel Opener Retigabine on Inflammatory Pain in Mice

作　　者：陈衍铭 黄超男 肖欣怡 庄涛 CHEN Yanming;HUANG Chaonan;XIAO Xinyi;ZHUANG Tao(School of Pharmacy,Jiangsu Ocean University,Lianyungang 222000,China)

机构地区：[1]江苏海洋大学药学院,江苏连云港222000

出　　处：《云南师范大学学报（自然科学版）》2023年第5期74-78,共5页Journal of Yunnan Normal University:Natural Sciences Edition

基　　金：江苏省高等学校重点学科发展计划资助项目(2022JSPAPD006);江苏省高等学校自然科学研究面上资助项目(21KJB350002).

摘　　要：通过醋酸扭体模型、福尔马林致痛模型和角叉菜胶诱导的炎症性疼痛模型评价Kv7通道开放剂瑞替加滨对炎症性疼痛的镇痛作用.此外,使用Kv7通道拮抗剂XE991来评估瑞替加滨对角叉菜胶诱导的机械痛的镇痛作用是否能被逆转.在上述三种炎症性疼痛模型中,瑞替加滨均能以剂量依赖性方式发挥镇痛作用.瑞替加滨(10 mg/kg)的镇痛作用能被XE991(3 mg/kg)显著拮抗.瑞替加滨能有效抑制小鼠炎症性疼痛,证明靶向激活Kv7通道的策略可能对治疗炎症性疼痛有效.The analgesic effects of Kv7 channel opener retigabine on inflammatory pain were evaluated by a acetic acid writhing test,a formalin-induced pain model,and a carrageenan-induced inflammatory pain model in this study.In addition,the Kv7 channel antagonist XE991 was used to assess whether the analgesic effect of retigabine on carrageenan-induced mechanical allodynia could be reversed.In all three inflammatory pain models described above,retigabine exerted analgesic effects in a dose-dependent manner.The analgesic effect of retigabine(10 mg/kg)was significantly antagonised by XE991(3 mg/kg).Retigabine was effective in suppressing inflammatory pain in mice and the strategy of targeted activation of Kv7 channels may prove to be effective in the treatment of inflammatory pain.

关 键 词：Kv7钾通道开放剂 瑞替加滨 炎症性疼痛 镇痛 XE991 

分 类 号：R971.1[医药卫生—药品]