旋毛虫感染免疫逃逸机制研究进展  

Research progress on the immune evasion mechanism in Trichinella spiralis infection

作　　者：张旭 孙希萌[2] ZHANG Xu;SUN Ximeng(Grade 2021 Class 5,Clinical Medicine,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Department of Medical Microbiology and Parasitology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学基础医学院2021级“5+3”临床医学专业5班,北京100069 [2]首都医科大学基础医学院病原生物学系,北京100069

出　　处：《中国寄生虫学与寄生虫病杂志》2023年第4期492-496,501,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：北京市自然科学基金面上项目(7222007);首都医科大学长学制导师项目(CXZDS2022010)。

摘　　要：旋毛虫感染可引起严重危害人类健康的人兽共患旋毛虫病。旋毛虫生活史的各个阶段均能影响宿主的免疫应答。免疫逃逸机制是一种常见的自然选择机制,是病原体在自然选择下对免疫系统的一种适应,可使病原体能解除或缓解人体的免疫应答,躲避来自免疫系统的攻击,确保其能继续生存、繁殖。本文综述了旋毛虫免疫逃逸机制在干扰固有免疫反应和适应性免疫反应等方面的研究进展。深入研究旋毛虫的免疫逃逸机制对旋毛虫病的防控、人体自身免疫性疾病和过敏性疾病的治疗有重要意义。Trichinella spiralis infection can cause zoonotic trichinellosis that seriously endangers human health.During the entire T.spiralis life cycle stages,the parasite can manipulate the host's immune responses.The immune evasion mechanism,as a common natural selection mechanism,is an adaptation of pathogens to the immune system under natural selection.It enables the pathogens to relieve or alleviate the host's immune responses,avoid attacking from the immune system,and ensure that they can survive and reproduce.This paper reviewed the research advance of T.spiralis immune evasion mechanism in disturbing complement response,innate immune response,humoral immune response,and T cell immune response.Further research of the immune evasion mechanism of T.spiralis is of great significance for the prevention and control of trichinosis,the treatment of human autoimmune diseases,and allergic diseases.

关 键 词：旋毛虫 免疫逃逸 免疫应答 免疫治疗 

分 类 号：R383.15[医药卫生—医学寄生虫学]