光/电化学驱动螺环化合物的合成研究进展  

Research Progress in Synthesis of Spirocyclic Compounds Driven by Photo/Electrochemistry

作　　者：陈宁[1] 张成栋 李鹏 仇格 刘颖杰 张天雷 Chen Ning;Zhang Chengdong;Li Peng;Qiu Ge;Liu Yinjie;Zhang Tianlei(School of Pharmacy,Harbin University of Commerce,Harbin 150076;Heilongjiang Nursing College,Harbin 150086;School of Chemistry and Chemical Engineering,Yantai University,Yantai,Shandong 264005)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076 [2]黑龙江护理高等专科学校,哈尔滨150086 [3]烟台大学化学化工学院,山东烟台264005

出　　处：《有机化学》2023年第7期2293-2303,共11页Chinese Journal of Organic Chemistry

基　　金：黑龙江省博士后科研启动金(No.LBH-Q20103);高校学科协同创新成果建设培育(No.LJGXCG2022-086)资助项目.

摘　　要：螺环作为一种重要的有机分子骨架,在有机化学、药物化学、材料科学等领域中广泛存在.由于螺环骨架具有较大的三维空间结构,满足药物设计中对构象刚性的需求,因此开发高效的螺环化合物的合成方法尤为重要.近年来,光催化和电催化作为绿色、高效的合成手段,为螺环化合物的合成注入了新的潜力.主要按螺[4.5]类骨架、螺[5.5]类骨架、螺[2.3]类骨架以及螺吲哚类骨架的构建进行了分类,并从光催化和电催化合成两个方面对螺环化合物的构建进行了综述.As important organic molecular frameworks,spirocycles exist widely in organic chemistry,medicinal chemistry,material science and other fields.Since the spirocyclic skeleton has a large three-dimensional space structure,which meets the demand for conformational rigidity in drug design,it is particularly important to develop efficient synthetic methods for spirocyclic compounds.In recent years,photocatalysis and electrocatalysis have injected new potential into the synthesis of spirocyclic compounds as green and efficient synthetic methods.This article is mainly classified by the construction of snail[4.5]skeleton,snail[5.5]skeleton,snail[2.3]skeleton,and spiro-indoles skeleton.Moreover,the construction of spirocyclic compounds is reviewed from two aspects:photocatalysis and electrocatalytic synthesis.

关 键 词：螺环 光催化 电催化 

分 类 号：O624[理学—有机化学]