基于α-氢迁移策略构建杂环骨架的研究进展  

Research Progress on Construction of Heterocyclic Skeletons Based onα-Hydride Transfer Strategy

作　　者：陈玉琢 孙红梅 王亮[1] 胡方芝 李帅帅 Chen Yuzhuo;Sun Hongmei;Wang Liang;Hu Fangzhi;Li Shuaishuai(College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao,Shandong 266109)

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109

出　　处：《有机化学》2023年第7期2323-2337,共15页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21978144,22208184);山东省高等学校青创科技计划(No.2019KJM002)资助项目.

摘　　要：杂环化合物的高效构建是有机合成领域的重要课题,[m+n]环化反应可将两个相对简单易得的反应底物进行组合,是构建环状骨架的重要手段.基于负氢迁移策略的[m+n]环化反应将两个相对易得的底物原位生成负氢受体,避免反应底物的预制,具有高的原子和步骤经济性.选取基于负氢迁移策略的[m+n]环化反应为研究对象,从通过该类反应所构建的氮杂、氧杂环骨架着手,按照生成氮杂、氧杂环的大小进行分类,综述了2018年以来基于负氢迁移策略的[m+n]环化反应的研究进展,并对该领域的发展方向进行了展望.The efficient construction of heterocyclic compounds is an important topic in the field of organic synthesis.[m+n]cyclization reaction can form privilege molecules from the combination of two readily available reaction substrates,which is an important means for construction of cyclic skeletons.The[m+n]cyclization reaction based on hydride transfer strategy can in situ generate hydride acceptor from two relatively simple substrates,avoiding the prefabrication of reaction substrates,which features high atom and step economy.In this review,the[m+n]cyclization reactions based on hydride transfer strategy are selected as the research object.Starting from the framework of aza-and oxa-heterocycles constructed by this kind of reaction,this review is classified according to the size of the generated aza-and oxa-heterocycles.The recent progress of[m+n]cyclization based on hydride transfer strategy since 2018 is summarized,and the development of this field is also prospected.

关 键 词：杂环化合物 负氢迁移策略 [m+n]环化反应 原位生成负氢受体 

分 类 号：O626[理学—有机化学]