非共轭丁烯内酯α-和β-位反应研究进展  

Advances on theα-andβ-Reactions of Deconjugated Butenolides

作　　者：周林 杨鸿 杨川 赵志刚[1] 李清寒[1] Zhou Lin;Yang Hong;Yang Chuan;Zhao Zhigang;Li Qinghan(College of Chemistry and Environment,Southwest Minzu University,Chengdu 610041)

机构地区：[1]西南民族大学化学与环境学院,成都610041

出　　处：《有机化学》2023年第7期2407-2424,共18页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22001219);四川省自然科学基金(No.2022NSFSC1189)资助项目.

摘　　要：γ-内酯衍生物大多具有抗炎、抗肿瘤和抗癌等生物活性,发展γ-内酯衍生物的构建方法在有机合成中具有重要价值.其中,以非共轭丁烯内酯为起始原料的构建方案呈现出巨大的潜力和无可比拟的优势,是最直接、高效的方法,受到化学家的广泛关注,是近年来有机合成研究热点之一.综述了非共轭丁烯内酯α-和β-位参与的反应研究进展,重点概述了各类反应体系的特点,并对部分反应的机理进行了讨论.同时,对该领域未来发展方向进行了展望.Developing the construction methods ofγ-lactone derivatives due to their anti-inflammatory,antitumor,anti-cancer and other biological activities has important value in organic synthesis.Among them,the deconjugated butenolides have shown great potential and advantages in the synthesis ofγ-lactone derivatives.As the direct and efficient method,it has attracted more attentions of chemists,and is one of the hot topics of organic synthesis in recent years.Theα-andβ-reactions of deconjugated butenolides are reviewed,in which the characteristics of various reaction systems and the mechanisms of some reactions are discussed.At the same time,the future development is prospected in this field.

关 键 词：非共轭丁烯内酯 α-加成 β-加成 亲核进攻 串联环化 

分 类 号：O623.624[理学—有机化学]