裸花紫珠叶中两个新的半日花烷型二萜  

Two New Labdane Diterpenoids from the Leaves of Callicarpa nudiflora

作　　者：余章昕[1] 蒙玉琴 薛萌琳 李小宝[1] 陈光英[1] 韩长日 Yu Zhangxin;Meng Yuqin;Xue Menglin;Li Xiaobao;Chen Guangying;Han Changri(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province,Hainan Vocational University of Science and Technology,Haikou 571126)

机构地区：[1]海南师范大学化学与化工学院热带药用资源化学教育部重点实验室热带药用植物化学海南省重点实验室,海口571158 [2]海南科技职业大学药食同源植物资源海南省重点实验室,海口571126

出　　处：《有机化学》2023年第7期2567-2571,共5页Chinese Journal of Organic Chemistry

基　　金：海南省重点研发项目(Nos.ZDYF2022SHFZ286,ZDYF2021SHFZ072);海南省自然科学基金(No.221MS034);海南省教育厅项目(No.Hnky2021-30);国家自然科学基金(No.21662012);海南省院士创新平台(No.YSPTZX202030);中央引导地方科技发展资金(No.ZY2022HN08)资助项目.

摘　　要：从裸花紫珠叶子中分离纯化得到2个新的半日花烷型二萜化合物3-氧代-7-羟基-半日花烷-8(17),13E-烯-15-酸(1)、3-氧代-8-羟基-半日花烷-13E-烯-15-酸(2)及5个已知的萜类化合物,其结构通过核磁共振(NMR)、高分辨电喷雾电离质谱(HRESIMS)等多种现代波谱技术进行确定,化合物1的绝对构型通过单晶衍射确定.评价了所有化合物对脂多糖(LPS)诱导小鼠巨噬细胞RAW 264.7产生一氧化氮(NO)的抑制作用,结果显示新化合物1和2表现出较好的抗炎活性,其IC_(50)值分别为(10.3±0.3)和(12.7±0.4)μmol/L.Two new labdane diterpenoids 3-oxo-7-hydroxy-8(17),13E-labdadien-15-oic acid(1),3-oxo-8-hydroxy-13E-labden-15-oic acid(2),and five known terpenoids were obtained from the leaves of Callicarpa nudiflora during a systematic phytochemical investigation.The structures were elucidated using comprehensive spectroscopic methods[nuclear magnetic resonance spectroscopy(NMR)and high resolution electrospray ionization mass spectroscopy(HR-ESI-MS)],and the absolute configuration of 1 was established based on single-crystal X-ray diffraction.The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced(LPS)mouse leukemia cells of monocyte macrophage(RAW 264.7)cells was evaluated.Compounds 1 and 2 showed potential anti-inflammatory activity with IC_(50)values of(10.3±0.3)and(12.7±0.4)μmol/L,respectively.

关 键 词：裸花紫珠 半日花烷型二萜 倍半萜 抗炎 

分 类 号：TQ464.2[化学工程—制药化工]