可见光诱导C—N键断裂构建C—C键的研究进展  

Research Progress of Visible Light Promoted C—N Bond Fracture to Construct C—C Bond

作　　者：普佳霞 贾小英 韩丽荣 李清寒[1] Pu Jiaxia;Jia Xiaoying;Han Lirong;Li Qinghan(College of Chemistry and Environment,Southwest Minzu University,Chengdu 610041)

机构地区：[1]西南民族大学化学与环境学院,成都610041

出　　处：《有机化学》2023年第8期2591-2613,共23页Chinese Journal of Organic Chemistry

基　　金：西南民族大学中央高校学生项目(No.2022NYXXS085);四川省科技厅科技支撑计划(No.2015NZ0033)资助项目。

摘　　要：近年来,可见光促进的光化学有机转化引起了广大有机化学家的兴趣.相比于传统方法,利用可见光作为可再生能源的光氧化还原催化已被证明是一种温和而强大的工具,可以通过单电子转移(SET)过程促进有机分子的活化.在许多天然产物的结构中存在大量的氨基功能团,同时氨基也是一些药物分子和功能材料的重要结构单元.因此,通过对这些物质分子中的C—N键进行活化而进行C—C键形成的偶联反应,则可以对该类化合物进行有效的结构修饰,从而得到具有多种结构及功能化的化合物.因此,这方面的研究现已成为了有机合成的一个重要研究领域.综述了近年来通过可见光促进C—N键断裂及其在C—C键形成反应研究中的应用研究成果,讨论了代表性的例子及其反应机制.In recent years,the photochemical organic transformation promoted by visible light has aroused the interest of organic chemists.Compared with traditional methods,photoredox catalysis using visible light as renewable energy has been proved to be a mild and powerful tool,which can promote the activation of organic molecules by single electron transfer(SET)process.There are a lot of amino functional groups in the structures of many natural products,and amino groups are also important structural units of some drug molecules and functional materials.Therefore,by activating the C—N bond in these substances and carrying out some coupling reactions of C—C bond formation,the structure of these compounds can be effectively modified,so as to obtain compounds with various structures and functionalization.Therefore,this study has become an important research field of organic synthesis.The research results of C—N bond breaking promoted by visible light and its application in the study of C—C bond formation reaction in recent years are reviewed,and representative examples and reaction mechanisms are discussed.

关 键 词：重氮盐 铵盐 Katritzky盐 光催化 C—N键断裂 C—C键形成 研究进展 

分 类 号：O641.1[理学—物理化学]