钯催化共轭二烯的不对称氢官能团化  

Palladium-Catalyzed Asymmetric Hydrofunctionalizations of Conjugated Dienes

作　　者：王玉超 刘晋彪[1] 何智涛 Wang Yuchao;Liu Jinbiao;He Zhitao(Faculty of Materials Metallurgy and Chemistry,Jiangxi University of Science and Technology,Ganzhou,Jiiangxi 341000;CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Shanghai 200032;University of Chinese Academy of Sciences,Beijing 100049)

机构地区：[1]江西理工大学材料冶金化学学部,江西赣州341000 [2]中国科学院上海有机化学研究所、中国科学院天然产物有机合成化学重点实验室,上海200032 [3]中国科学院大学,北京100049

出　　处：《有机化学》2023年第8期2614-2627,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22071262);上海市科学技术委员会(No.22ZR1475200);上海市启明星计划(No.20QA1411300)资助项目。

摘　　要：由于原料来源广泛、高原子经济性和高立体选择性控制等优势,钯催化共轭二烯的不对称氢官能团化已发展成为一种高效合成手性烯丙基片段的方法,包括构建烯丙基C—C、C—N、C—S、C—P、C—Si和C—O键等.总结了近几十年来该领域的发展现状、最新进展以及机制特点等.根据所构建的化学键的不同,主要涵盖了不对称氢烷基化、氢胺化、氢膦化、氢砜化、氢硅化和氢醚化六个部分.Because of the broad substrate availability,high atom economy and efficient stereocontrol,palladium-catalzyed asymmetric hydrofunctionalizations of conjugated dienes have emerged as an efficient route to construct enantioenriched allylic motifs,including allylic C—C,C—N,C—S,C—P,C—Si and C—O bonds.The development,advance and mechanistic features of this area in the past decades are summarized.Based on the types of allylic stereogenic centers constructed via this strategy,the review is divided into six parts,including asymmetric hydroalkylation,hydroamination,hydrophosphinylation,hydrosulfonylation,hydrosilylation and hydroalkoxylation.

关 键 词：钯催化 共轭二烯 氢官能团化 不对称合成 

分 类 号：O621.251[理学—有机化学]