光/电催化醚α-位官能团化研究进展  

Progress ofα-Position Functionalization of Ethers under Photo/Electrocatalysis

作　　者：刘颖杰 石岗庆 仇格 张鑫[3] 宋冬雪 陈宁[1] 于淼 许颖 Liu Yingjie;Shi Gangqing;Chou Ge;Zhang Xin;Song Dongxue;Chen Ning;Yu Miao;Xu Ying(School of Pharmacy,Harbin University of Commerce,Harbin 150076;School of Chemistry and Chemical Engineering,Yantai University,Yantai 264005;The First Affiliated Hospital of Harbin Medical University,Harbin 150001)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076 [2]烟台大学化学化工学院,烟台264005 [3]哈尔滨医科大学附属第一医院,哈尔滨150001

出　　处：《有机化学》2023年第8期2664-2681,共18页Chinese Journal of Organic Chemistry

基　　金：黑龙江省自然科学基金(No.LH2020H068);黑龙江省教育厅创新人才(No.UNPYSCT-2018139);高校学科协同创新成果建设培育(No.LJGXC-G2022-086)资助项目。

摘　　要：醚类化合物由于其优异的物理化学性质广泛应用于有机化学、材料科学、生物医药等领域.其中,四氢呋喃/四氢噻吩及其衍生物更是构建生物活性分子和复杂的天然产物的核心骨架.光/电催化因其符合绿色化学要求,以及大多涉及自由基中间体的独特路径,近年来已逐步成为化学家们合成新颖化合物的重要手段.利用光/电催化实现醚类化合物α-位的官能团化是一种绿色、高效的合成策略.因此,以氧醚/硫醚为例,综述了光/电催化醚类化合物α-位官能团化的研究进展,并对部分机理做了详细的介绍.Ethers are widely used in organic chemistry,materials science,biomedicine and other fields due to their excellent physicochemical properties.Among them,tetrahydrofuran/tetrahydrothiophene and their derivatives are the core backbones for building biologically active molecules and complex natural products.In recent years,photo/electrocatalysis has gradually become an important tool for chemists to synthesize novel compounds due to its compliance with the requirements of green chemistry and the unique pathway that mostly involves radical intermediates.The functionalization ofα-positions of ethers using photo/electrocatalysis is a green and efficient synthetic strategy.Therefore,the research progress of photo/electrocatalytic functionalization of ether compounds at theα-position is reviewed with ether/sulfide as examples,and a detailed description of some of the mechanisms is provided.

关 键 词：醚类化合物 光催化 电催化 光电协同催化 官能团化 

分 类 号：O621.251[理学—有机化学] O644.1[理学—化学]