水相中抗坏血酸钠促进铁催化合成含硫芳香伯胺化合物  

Fe-Catalyzed Synthesis of Sulfide-Based Aromatic Primary Amines in Water Promoted by Sodium-Ascorbate

作　　者：陈乡萍 孟晨湘 李梦娜 楚尚敏 朱欣欣 许凯[2] 刘澜涛[2,3] 王涛[2] 张凤华[1] 李飞[1] Chen Xiangping;Meng Chenxiang;Li Mengna;Chu Shangmin;Zhu Xinxin;Xu Kai;Liu;Lantao;Wang Tao;Zhang Fenghua;Li Fei(College of Petrochemical Engineering,Liaoning Petrochemical University,Fushun,Liaoning 113001;Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals,College of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu,Henan 476000;College of Chemistry,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]辽宁石油化工大学石油化工学院,辽宁抚顺113001 [2]商丘师范学院化学化工学院、药物绿色合成河南省工程实验室,河南商丘476000 [3]郑州大学化学学院,郑州450001

出　　处：《有机化学》2023年第8期2800-2807,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21572126,21202095);河南省科技创新团队建设计划(No.C20150030);河南省高校科技创新人才支持计划(No.184100510011);河南省自然科学基金(No.212300410379);河南省科技攻关项目(No.192102110222);河南省高等学校青年骨干教师培养计划(No.2021GGJS136);河南省商丘市人才支持计划领军人才(No.SQRC202212004)资助项目.

摘　　要：水相中在抗坏血酸钠的促进下,铁催化硝基取代的芳基氟代物与硫酚合成含硫芳香伯胺化合物.该方法可构建C—S键并原位还原硝基.这种水相中“一锅”两步反应的显著特点包括直接使用毒性较低的铁催化剂和天然存在的抗坏血酸钠添加剂,得到中等至优秀的收率,表现出良好的官能团耐受性以及可扩量能力.A practical method for Fe-catalyzed and sodium-ascorbate-promoted synthesis of sulfide-based aromatic primary amines in water from nitroaryl fluorides and thiols has been established.This protocol enables the construction of C—S bonds and the reduction of nitro groups in situ.The remarkable features of this one-pot two-step reaction in water include the direct usage of both a less toxic iron catalyst and naturally occurring sodium-ascorbate as the additive,mostly decent to excellent yields,good functional group tolerance as well as the ability to be scaled up.

关 键 词：水相反应 还原反应 铁 催化 芳香伯胺 

分 类 号：O625.63[理学—有机化学]