铑催化碳酸亚乙烯酯与吲哚啉C(7)位C—H甲酰甲基化反应  

Rh(III)-Catalyzed C(7)—H Formylmethylation of Indoline with Vinylene Carbonate

作　　者：张彦波 孙萌[1] Zhang Yanbo;Sun Meng(Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi'an 710127)

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子教育部重点实验室,西安710127

出　　处：《有机化学》2023年第8期2905-2912,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21702160)资助项目.

摘　　要：发展了一种铑催化碳酸亚乙烯酯与吲哚啉C(7)位C—H甲酰甲基化反应合成芳基乙醛化合物的高效方法.该反应条件温和,区域选择性专一,底物官能团兼容性好,产物收率较高.A Rh(III)-catalyzed synthesis of arylacetaldehydes via C—H formylmethylation with vinylene carbonate has been developed.The reaction proceeded smoothly to give C7-functionalized N-(2-pyrimidyl)-indolines in moderate to good yields.This protocol features simple system,excellent regioselectivity,and good functional group compatibility.

关 键 词：铑催化 甲酰甲基化 吲哚啉 碳酸亚乙烯酯 

分 类 号：O625.41[理学—有机化学]