二乙酰吗啡成瘾及神经毒性作用机制研究进展  

Research progress of diacetylmorphine in addiction and neurotoxic mechanisms

作　　者：谢明仁 袁霞 俞蕾 何天晓 张璟[2] 俞发荣 XIE Mingren;YUAN Xia;YU Lei;HE Tianxiao;ZHANG Jing;YU Farong(School of Public Security,Gansu University of Political Science and Law,Lanzhou 730070,China.;Gansu Center for Disease Control and Prevention,Lanzhou 730000)

机构地区：[1]甘肃政法大学公安分院,兰州730070 [2]甘肃省疾病预防控制中心,兰州730000

出　　处：《中国实验动物学报》2023年第8期1085-1090,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：甘肃省自然科学基金(21JR7RA571);甘肃政法大学重点项目(GZF2021XZD06);甘肃政法大学科研创新团队项目;兰州市科技计划项目(2022-2-68)。

摘　　要：二乙酰吗啡(diacetylmorphine,DAM)是一种具有极强依赖性的中枢性兴奋剂,长期滥用会产生严重的神经毒性症状。DAM是我国滥用人数最多的毒品,已成为危害社会稳定的严重公共卫生问题。DAM可以诱导神经细胞发生凋亡,对人体健康产生极大的影响。本文对DAM成瘾和戒断机制以及对神经因子的影响作一综述,为DAM对神经细胞毒性作用机制研究提供理论依据。Diacetylmorphine(DAM)is a highly dependent central stimulant that produces severe neurotoxic effects over a long period.DAM is the most abused drug in our country and has become a serious public health issue endangering social stability.DAM induces nerve cell apoptosis,which has a great influence on human health.In this article,the mechanism of DAM addiction and withdrawal as well as its effects on neural factors are reviewed,providing a theoretical basis to study the mechanism of DAM toxicity in nerve cells.

关 键 词：二乙酰吗啡 成瘾 神经毒性作用 

分 类 号：Q95-33[生物学—动物学]