益生菌对过敏性哮喘患儿炎症因子及氧化应激标志物的影响  

Effects of Probioticson Inflammatory Factors and Oxidative Stress Markers in Children with Allergic Asthma

作　　者：郦银芳[1] 孔霞[1] 吴红梅[1] Li Yinfang;Kong Xia;Wu Hongmei(Nanjing Hospital Affiliated to Nanjing Medical University,the First Hospital of Nanjing,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院,南京市第一医院,南京210006

出　　处：《儿科药学杂志》2023年第10期45-48,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨益生菌对过敏性哮喘患儿体内炎症因子及氧化应激标志物水平的影响。方法:选取2016年2月至2019年12月南京市第一医院哮喘门诊确诊的62例过敏性哮喘患儿,随机分为对照组和观察组各31例。对照组仅予以常规抗哮喘治疗,观察组在对照组治疗基础上予以口服益生菌。采用儿童哮喘控制测试(C-ACT)量表比较两组患儿治疗前后哮喘控制效果,记录第1秒用力呼气容积(FEV1)、FEV1占肺活量(FVC)百分比(FEV1/FVC)、呼气峰流速(PEF),检测血清中白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)水平。结果:治疗前,两组患儿哮喘控制效果、FVC、FEV1、PEF,血清IL-4、IFN-γ、MDA、SOD、GSH水平比较差异均无统计学意义(P>0.05)。治疗后,两组患儿哮喘控制效果、FVC、FEV1、PEF均较治疗前显著改善,且观察组改善程度优于对照组(P均<0.05);两组患儿IL-4、MDA水平均较治疗前明显降低,且观察组较对照组降低更明显(P均<0.05)。两组患儿IFN-γ、SOD、GSH水平均较治疗前明显升高,且观察组较对照组升高更明显(P均<0.05)。结论:益生菌辅助治疗可改善过敏性哮喘患儿哮喘控制效果及肺功能,降低哮喘患儿体内促炎因子及氧化应激标志物水平,增加抗炎因子及抗氧化物表达水平。因此,益生菌可能通过抗炎及抗氧化作用机制干预哮喘,是潜在的辅助治疗哮喘的药物。Objective:To explore the effects of probiotics on levels of inflammatory factors and oxidative stress markers in children with allergic asthma.Methods:A total of 62 children diagnosed with allergic asthma at the asthma outpatient department of the First Hospital of Nanjing from Feb.2016 to Dec.2019 were randomly divided into the control group and observation group,with 31 cases in each group.The control group received routine anti-asthmatic treatment,while the observation group was given oral probiotics based on the control group.The children’s asthma control test(C-ACT)was used to compare the asthma control effects before and after treatment in both groups.The forced expiratory volume at one second(FEV1),FEV1/forced vital capacity(FVC),and peak expiratory flow(PEF)were recorded.The levels of interleukin-4(IL-4),interferon-γ(IFN-γ),malondialdehyde(MDA),superoxide dismutase(SOD)and reduced glutathione(GSH)in the serum were measured.Results:Before treatment,there were no significant differences in asthma control effects,FVC,FEV1,PEF,IL-4,IFN-γ,MDA,SOD and GSH levels between two groups(P>0.05).After treatment,both groups showed significant improvements in asthma control effects,FVC,FEV1 and PEF compared with those before treatment,and the observation group was better than the control group(P<0.05).The IL-4 and MDA levels in both groups decreased significantly after treatment,with a more significant decrease in the observation group compared with the control group(P<0.05).The levels of IFN-γ,SOD and GSH in both groups increased significantly after treatment,with a more significant increase in the observation group compared with the control group(P<0.05).Conclusion:Probiotic supplementation can improve asthma control effects and pulmonary function in children with allergic asthma,reduce the levels of pro-inflammatory factors and oxidative stress markers,and increase the expression levels of anti-inflammatory factors and antioxidants.Therefore,probiotics may potentially serve as the adjunctive treatment for asthm

关 键 词：支气管哮喘 白细胞介素-4 Γ-干扰素 丙二醛 超氧化物歧化酶 

分 类 号：R726.5[医药卫生—儿科]