芎芍胶囊治疗动脉粥样硬化作用机制的研究进展  

Research progress on the mechanism of Xiongshao Capsules in the treatment of atherosclerosis

作　　者：陈利捷 金宇[2] 陈启庭[2] 许贵鹏 张淼 CHEN Lijie;JIN Yu;CHEN Qiting;XU Guipeng;ZHANG Miao(Guangxi University of Chinese Medicine,Nanning 530001,China;Shenzhen Second People′s Hospital,Shenzhen 518000,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]深圳市第二人民医院,广东深圳518000

出　　处：《药学研究》2023年第9期708-713,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金青年基金(No.82104770);广东省自然科学基金面上项目(No.2022A1515011456);深圳医疗卫生三名工程(No.SZSM201612049)。

摘　　要：动脉粥样硬化(AS)是心脑血管疾病主要的病理基础,近年来AS的发病机制研究逐步深入,诊治手段也不断更迭。活血消瘀制剂芎芍胶囊是陈可冀院士根据复方血府逐瘀汤精简制成,主要由川芎与赤芍组成,对AS、血脂异常、PCI术后再狭窄及冠心病等疗效显著,安全性高,但其具体机制目前仍不明朗。本文对芎芍胶囊治疗AS的基础与临床研究进展进行综述,以期为临床治疗AS的合理用药提供科学依据。Atherosclerosis(AS)is the main pathological basis of cardiovascular and cerebrovascular diseases.In recent years,the pathogenesis of AS has been progressively researched and the diagnostic and therapeutic tools have been constantly changed.Xiongshao Capsules,a blood activating and blood stasis eliminating preparation,is made by Academician Chen Keji based on the Compound Xuefu Zhuyu Decoction and is mainly composed of Chuanxiong and Radix Paeoniae.It has significant efficacy and high safety in treating AS,dyslipidemia,restenosis after PCI,and coronary heart disease,but its specific mechanism is still unclear.This article reviewed the basic and clinical research progress of Xiongshao Capsules in the treatment of AS,with a view to providing scientific basis for the rational use of drugs in the clinical treatment of AS.

关 键 词：芎芍胶囊 动脉粥样硬化 冠心病 活血化瘀 

分 类 号：R543.5[医药卫生—心血管疾病]