扶正祛风汤治疗气虚型慢性荨麻疹的效果及对C反应蛋白、血清淀粉样蛋白A、D-二聚体水平的影响  

Effect of Fuzheng Qufeng Decoction on treating chronic urticaria of Qi deficiency type and its influence on C-reactive protein,serum amyloid A,and D-dimer levels

作　　者：麻安喆 莫薇[2] 陈婧婧[3] MA Anzhe;MO Wei;CHEN Jingjing(Clinical Laboratory,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi Zhuang Autonomous Region,Guilin 541002,China;General Medicine,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi Zhuang Autonomous Region,Guilin541002,China;Department of Dermatological,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi Zhuang Autonomous Region,Guilin 541002,China)

机构地区：[1]广西壮族自治区桂林市中医医院检验科,广西桂林541002 [2]广西壮族自治区桂林市中医医院综合内科,广西桂林541002 [3]广西壮族自治区桂林市中医医院皮肤科,广西桂林541002

出　　处：《中国医药导报》2023年第26期161-164,共4页China Medical Herald

基　　金：广西壮族自治区中医药管理局自筹经费科研项目(GZZC2020311)。

摘　　要：目的探讨扶正祛风汤治疗气虚型慢性荨麻疹(CU)的效果及对C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、D-二聚体(D-D)水平的影响。方法采用随机数字表法将2020年1月至2022年1月广西壮族自治区桂林市中医医院收治的98例气虚型CU患者分为两组,各49例。对照组接受氯雷他定片和维生素C片治疗,观察组接受扶正祛风汤治疗,均连续治疗14 d。比较两组临床疗效和治疗前后中医证候积分、7日荨麻疹活动度评分(UAS7)、慢性荨麻疹生活质量问卷(GU-Q2oL)及CRP、SAA、D-D水平。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分,UAS7、GU-Q2oL评分较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血浆CRP、SAA、D-D水平较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论扶正祛风汤治疗气虚型CU效果确切,能有效改善皮损和瘙痒症状,其机制可能与调节炎症和凝血因子水平有关。Objective To explore the effect of Fuzheng Qufeng Decoction on the treatment of chronic urticaria(CU)with qi deficiency type and its influence on C-reactive protein(CRP),serum amyloid A(SAA),and D-dimer(D-D)levels.Methods A total of 98 CU patients with qi deficiency type admitted to Guilin Municipal Hospital of Traditional Chinese Medicine from January 2020 to January 2022 were selected and divided into two groups according to the random number table method,with 49 cases in each group.The control group received Loratadine Tablets and Vitamin C Tablets,and the observation group received Fuzheng Qufeng Decoction,all treated continuously for 14 d.The clinical efficacy,traditional Chinese medicine syndrome scores,7-day Urticaria Activity Decoction(UAS7),chronic urticaria quality of life questionnaire(GU-Q2oL),and levels of CRP,SAA,and D-D were compared between two groups before and after treatment.Results The clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores,UAS7,and GU-Q2oL scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the plasma levels of CRP,SAA and D-D in both groups were lower than before treatment,and the observation group was lower than the control group the differences were statistically significant(P<0.05).Conclusion Fuzheng Qufeng Decoction has a definite therapeutic effect on CU of qi deficiency type,and can effectively improve skin lesions and itching symptoms.Its mechanism may be related to regulating inflammation and coagulation factor levels.

关 键 词：慢性荨麻疹 气虚型 扶正祛风汤 C反应蛋白 血清淀粉样蛋白A D-二聚体 

分 类 号：R275.9[医药卫生—中西医结合]