特应性皮炎患儿血清维生素D水平和补充维生素D疗效的系统评价  

Systematic evaluation of serum vitamin D levels and efficacy of vitamin D supplementation in children with atopic dermatitis

作　　者：陈曦[1] 王佳宁 孙丹 闫小宁 李文彬 CHEN Xi;WANG Jianing;SUN Dan;YAN Xiaoning;LI Wenbin(The First Clinical Medical College,Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang712046,China;Department of Dermatology,Shaanxi Provincial Hospital of Chinese Medicine,Shaanxi Province,Xi’an710003,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712046 [2]陕西省中医医院皮肤科,陕西西安710003

出　　处：《中国医药导报》2023年第27期108-112,共5页China Medical Herald

基　　金：陕西省创新人才推进计划-重点科技创新团队计划项目(2017KCT-27);陕西省中医药管理局长安医学皮肤病流派传承工作室项目。

摘　　要：目的测定特应性皮炎(AD)患儿血清25羟维生素D[25(OH)D]水平,及对维生素D干预进行系统分析,评价补充维生素D治疗AD的效果。方法计算机检索PubMed、EMbase、中国知网、万方学术期刊数据库、维普中文期刊数据库自2010年1月至2022年11月维生素D与AD及维生素D治疗AD的相关文献,使用meta分析的方法对检索到的符合纳入标准的文献进行系统评价。结果纳入随机对照试验(RCT)5篇,病例对照研究15篇。RCT中,试验组湿疹面积及严重程度指数高于对照组[WMD=-3.79,95%CI(-6.38,-1.20),P=0.004];试验组欧洲特应性皮炎评分高于对照组[WMD=-6.06,95%CI(-10.12,-2.00),P=0.003]。病例对照研究中,AD患儿组血清25(OH)D水平低于对照组[SMD=-0.80,95%CI(-1.18,-0.41),P<0.0001]。结论AD患儿有很高的维生素D缺乏的风险,补充维生素D可改善AD患儿临床症状。Objective To determine serum 25-hydroxyvitamin D(25[OH]D)levels in children with atopic dermatitis(AD),and the effect of vitamin D supplementation on AD was evaluated by systematic analysis of vitamin D intervention.Methods The relevant literature on vitamin D and AD and vitamin D therapy for AD were searched by computer from PubMed,EMbase,CNKI,Wanfang Academic Journal Database,and VIP from January 2010 to November 2022.A meta-analysis method was used to systematically evaluate the retrieved literatures that met the inclusion criteria.Results Five randomized controlled trials(RCT)and 15 case-control studies were included.In RCT,eczema area and severity index in experimental group was higher than that in control group(WMD=-3.79,95%CI[-6.38,-1.20],P=0.004);the scoring of atopic dermatitis in experimental group was higher than that in control group(WMD=-6.06,95%CI[-10.12,-2.00],P=0.003).In the case-control study,serum 25(OH)D levels in AD children group were lower than that in control group(SMD=-0.80,95%CI[-1.18,-0.41],P<0.0001).Conclusion Children with AD are at high risk of vitamin D deficiency,and vitamin D supplementation can improve clinical symptoms in children with AD.

关 键 词：维生素D 特应性皮炎 系统评价 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]