尿苷对线粒体功能的影响  

Effect of uridine on mitochondrial function

作　　者：白雪仪 黄锭 谢盼 孙瑞强 周航 刘煜[1] BAI Xueyi;HUANG Ding;XIE Pan;SUN Ruiqiang;ZHOU Hang;LIU Yu(School of Life Sciences and Technology,China Pharmaceutical University,Nanjing 211100,Jiangsu,China;Cell Culture Process Development Department,Shanghai WuXi Biologics Co.,Ltd.,Shanghai 200131,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211100 [2]上海药明生物技术有限公司细胞培养工艺开发部,上海200131

出　　处：《生物工程学报》2023年第9期3695-3709,共15页Chinese Journal of Biotechnology

摘　　要：尿苷是生物体内必需的营养物之一,需将尿苷浓度维持在一定浓度水平才能维持胞内正常的生长代谢。近年来,有研究发现尿苷可通过多种机制缓解生物体炎症反应,并能参与胞内糖酵解等代谢途径,且可调节胞内糖基化、乙酰化等蛋白修饰作用。此外,其还能通过减轻胞内氧化应激、促进高能化合物合成等方式保护细胞免受缺氧性损伤。研究表明,这些保护作用与尿苷对线粒体功能的调节作用息息相关。因此,本文主要综述了尿苷及其代谢反应(物)对线粒体功能的研究进展。Uridine is one of the essential nutrients in organisms.To maintain normal cell growth and intracellular metabolism,the uridine must be maintained at certain concentration.Recent studies have shown that uridine can reduce inflammatory response in organisms,participate in glycolysis,and regulate intracellular protein modification,such as glycosylation and acetylation.Furthermore,it can protect cells from hypoxic injury by reducing intracellular oxidative stress,promoting high-energy compounds synthesis.Previous studies have shown that the protective effects of uridine are closely related to its effect on mitochondria.This review summarizes the effect of uridine on mitochondrial function.

关 键 词：尿苷 线粒体 线粒体ATP依赖性钾离子通道 嘧啶核苷酸池 

分 类 号：Q26[生物学—细胞生物学]