2型糖尿病患者甘油三酯葡萄糖指数与维生素D缺乏风险的相关性  

Correlation between triglyceride glucose index and risk of vitamin D deficiency in patients with type 2 diabetes

作　　者：王艳姣[1] 詹俊鲲[1] 杨悦[1] 刘志青[1] Wang Yanjiao;Zhan Junkun;Yang Yue;Liu Zhiqing(Department of Geriatrics,Institute of Aging and Geriatrics,the Second Xiangya Hospital of Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院老年医学科,中南大学衰老与老年疾病研究所,长沙410011

出　　处：《中国医师杂志》2023年第9期1319-1324,共6页Journal of Chinese Physician

基　　金：国家自然科学基金(81974223)。

摘　　要：目的探讨2型糖尿病(T2DM)患者甘油三酯葡萄糖(TyG)指数与维生素D缺乏(VDD)患病风险的相关性。方法纳入2020年2月至2023年2月期间入住中南大学湘雅二医院老年医学科的T2DM患者。收集患者的一般临床资料和生化检查资料,计算TyG指数。将研究对象按血清25羟维生素D[25(OH)D]水平分为VDD组和对照(CON)组,比较两组间的一般临床特征;采用Pearson秩相关分析研究TyG指数与25(OH)D的相关性;按TyG指数的三分位数,将研究对象分为三组(Q1、Q2、Q3组),采用logistic回归分析探索TyG指数与VDD患病风险的关联。结果本研究纳入526例T2DM患者,其中男312例,女214例,年龄37~78岁。VDD患者300例,占比57.03%,CON组226例。VDD患者TyG指数高于CON组(P<0.05),且TyG指数与血清25(OH)D水平呈负相关(P<0.05)。Logistic回归分析显示,与Q1组相比,Q3组患者VDD的患病风险是Q1组的2.892倍(OR=2.892,95%CI:1.865~4.485,P<0.001)。在校正了年龄、性别、吸烟、肥胖、胰岛素、口服降糖药、他汀类药物的使用以及血生化相关指标后,Q3组患者的患病风险是Q1组的2.303倍(OR=2.303,95%CI:1.288~4.117,P=0.005)。结论在T2DM患者中,TyG指数与血清25(OH)D水平呈负相关,高TyG指数的T2DM患者患VDD的风险增加,TyG指数可用于观察VDD发生的可能,有利于早期检出VDD患者。Objective To explore the correlation between the triglyceride glucose(TyG)index and the risk of vitamin D deficiency(VDD)in patients with type 2 diabetes(T2DM).Methods T2DM patients admitted to the Department of Geriatrics,the Second Xiangya Hospital of Central South University from February 2020 to February 2023 were included.We collected general clinical and biochemical data from patients and calculated the TyG index.Divide the study subjects into VDD group and control(CON)group based on serum 25 hydroxyvitamin D[25 hydroxyvitamin D,25(OH)D]levels,and compare the general clinical characteristics between the two groups;Pearson rank correlation analysis was used to study the correlation between TyG index and 25(OH)D;According to the third percentile of the TyG index,the study subjects were divided into three groups(Q1,Q2,Q3),and logistic regression analysis was used to explore the association between the TyG index and the risk of VDD.Results This study included 526 patients with T2DM,including 312 males and 214 females,aged 37 to 78 years old.There were 300 VDD patients,accounting for 57.03%,and 226 in the CON group.The TyG index of VDD patients was higher than that of the CON group(P<0.05),and there was a negative correlation between the TyG index and serum 25(OH)D levels(P<0.05).Logistic regression analysis showed that compared with the Q1 group,the risk of VDD in Q3 group patients was 2.892 times higher than that in Q1 group(OR=2.892,95%CI:1.865-4.485,P<0.001).After adjusting for age,gender,smoking,obesity,insulin,oral hypoglycemic drugs,statin use,and blood biochemical indicators,the risk of illness in the Q3 group was 2.303 times higher than that in the Q1 group(OR=2.303,95%CI:1.288-4.117,P=0.005).Conclusions In T2DM patients,the TyG index is negatively correlated with serum 25(OH)D levels.T2DM patients with high TyG index have an increased risk of VDD,and the TyG index can be used to observe the possibility of VDD occurrence,which is beneficial for early detection of VDD patients.

关 键 词：糖尿病 2型 甘油三酯 葡萄糖 维生素D缺乏 

分 类 号：R587.1[医药卫生—内分泌]