氟曲马唑乳膏联合制霉素阴道栓治疗霉菌性阴道炎的疗效及对血清炎症相关因子的影响分析  

Efficacy of flutrimazole cream combined with nysfungin vaginal suppository on fungal vaginitis and its influence on serum inflammation-related factors

作　　者：武晓琳 李攀 张铮铮 WU Xiao-lin;LI Pan;ZHANG Zheng-zheng(Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学,221002 [2]徐州医科大学附属医院,221006

出　　处：《中国现代药物应用》2023年第17期30-33,共4页Chinese Journal of Modern Drug Application

基　　金：江苏省研究生科研创新计划项目(项目编号:KYCX22_2914)。

摘　　要：目的探讨氟曲马唑乳膏联合制霉素阴道栓治疗霉菌性阴道炎的疗效及对血清相关炎症因子的影响。方法100例霉菌性阴道炎患者,根据治疗方法不同分为研究组与对照组,每组50例。对照组采用制霉素阴道栓治疗,研究组在对照组基础上联合氟曲马唑乳膏治疗。对比两组患者症状改善时间,治疗效果,治疗前后白带常规情况及霉菌清除效果,治疗前后血清炎症相关因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)]水平。结果研究组症状改善时间(4.00±1.30)d明显短于对照组的(4.80±2.01)d,差异有统计学意义(P<0.05)。研究组治疗总有效率98%明显高于对照组的82%,差异有统计学意义(P<0.05)。治疗后,两组清洁度正常率、白细胞正常率、过氧化氢正常率、霉菌清除率均高于本组治疗前,且研究组清洁度正常率78%、白细胞正常率90%、过氧化氢正常率48%、霉菌清除率94%均高于对照组的56%、72%、26%、80%,差异有统计学意义(P<0.05)。治疗后,两组CRP、IL-6、IL-8水平均低于本组治疗前,且研究组CRP(7.70±1.02)mg/L、IL-6(99.00±13.09)pg/ml、IL-8(13.90±1.48)μg/L低于对照组的(9.20±0.92)mg/L、(113.50±12.87)pg/ml、(16.60±1.30)μg/L,差异有统计学意义(P<0.05)。治疗后1个月复查,研究组复发率2%低于对照组的14%,差异有统计学意义(P<0.05)。结论氟曲马唑乳膏联合制霉素阴道栓治疗霉菌性阴道炎可改善患者的临床症状,提高临床疗效,改善阴道环境,降低炎症相关因子水平,且复发率低。Objective To discuss the efficacy of flutrimazole cream combined with nysfungin vaginal suppository on fungal vaginitis and its influence on serum inflammation-related factors.Methods A total of 100 patients with fungal vaginitis were divided into the study group and the control group according to different treatment methods,with 50 cases in each group.The control group was treated with nysfungin vaginal suppository,and the study group was treated with flutramazole cream on the basis of the control group.Both groups were compared in terms of symptom improvement time,therapeutic effect,leucorrhea routine before and after treatment,mold clearance effect,serum inflammation-related factors[C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)]levels before and after treatment.Results The symptom improvement time of(4.00±1.30)d in the study group was significantly shorter than that of(4.80±2.01)d in the control group,and the difference was statistically significant(P<0.05).The total effective rate of 98%in the study group was significantly higher than that of 82%in the control group,and the difference was statistically significant(P<0.05).After treatment,the normal rate of cleanliness,normal rate of leukocytes,normal rate of hydrogen peroxide,and mold clearance rate in both groups were higher than those before treatment in this group;in the study group,the normal rate of cleanliness was 78%,the normal rate of leukocytes was 90%,the normal rate of hydrogen peroxide was 48%,and the mold clearance rate was 94%,which were higher than those of 56%,72%,26%,and 80%in the control group;the differences were statistically significant(P<0.05).After treatment,the levels of CRP,IL-6 and IL-8 in both groups were lower than those before treatment in this group;the study group had CRP of(7.70±1.02)mg/L,IL-6 of(99.00±13.09)pg/ml and IL-8 of(13.90±1.48)μg/L,which were lower than those of(9.20±0.92)mg/L,(113.50±12.87)pg/ml and(16.60±1.30)μg/L in the control group;the differences were statistically significant(P<0.

关 键 词：氟曲马唑乳膏 制霉素阴道栓 霉菌性阴道炎 炎症相关因子 

分 类 号：R711.31[医药卫生—妇产科学]