直接经皮冠状动脉介入术中冠状动脉注射重组人尿激酶原对急性心肌梗死患者预后的影响研究  

Study on effect of intracoronary injection of recombinant human prourokinase for injection during primary percutaneous coronary intervention on prognosis of patients with acute myocardial infarction

作　　者：刘晓曦 卢晓海 向南坡 LIU Xiao-xi;LU Xiao-hai;XIANG Nan-po(Department of Cardiology,Beijing Changping Hospital,Beijing 102200,China)

机构地区：[1]北京市昌平区医院心内科,102200

出　　处：《中国现代药物应用》2023年第17期116-118,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨直接经皮冠状动脉(冠脉)介入术(PPCI)中冠脉注射重组人尿激酶原对急性心肌梗死(AMI)患者临床预后的影响。方法193例行PPCI手术的AMI患者,根据治疗方法不同分为试验组(99例)和对照组(94例)。对照组患者给予常规PPCI治疗,试验组患者在PPCI术中冠脉注射重组人尿激酶原治疗。比较两组肌钙蛋白I(cTnI)峰值,左室射血分数(LVEF)水平,主要不良心血管事件(MACEs)及出血事件发生情况,住院天数。结果试验组患者cTnI峰值(14.91±8.11)ng/ml低于对照组的(18.49±13.04)ng/ml,差异具有统计学意义(P<0.05)。两组患者术后24 h LVEF水平比较差异无统计学(P>0.05);试验组患者术后1个月LVEF(54.43±5.31)%高于对照组的(52.33±6.66)%,差异具有统计学意义(P<0.05)。两组MACEs及出血事件发生率比较差异均无统计学意义(P>0.05)。试验组住院时间(7.30±3.44)d短于对照组的(8.72±4.46)d,差异具有统计学意义(P<0.05)。结论PPCI中冠脉注射重组人尿激酶原可改善AMI患者近期心功能且不增加出血风险,缩短住院时间。Objective To discuss the effect of intracoronary injection of recombinant human prourokinase for injection during primary percutaneous coronary intervention(PPCI)on clinical prognosis of patients with acute myocardial infarction(AMI).Methods A total of 193 AMI patients undergoing PPCI surgery were divided into experimental group(99 cases)and control group(94 cases)according to different treatment methods.The control group was treated with conventional PPCI,and the experimental group was treated with intracoronary injection of recombinant human prourokinase for injection during PPCI.The peak value of cardiac troponin I(cTnI),the value of left ventricular ejection fractions(LVEF)measured within 24 h and 1 month,bleeding events and major adverse cardiovascular events(MACEs)in 1 month after operation,and total hospital days were observed.Both groups were compared in terms of peak value of cardiac troponin I(cTnI),the level of left ventricular ejection fraction(LVEF),the occurrence of major adverse cardiovascular events(MACEs)and bleeding events,and the length of hospital stay.Results The peak value of cTnI of(14.91±8.11)ng/ml in the experimental group was lower than that of(18.49±13.04)ng/ml in the control group,and the difference was statistically significant(P<0.05).24 h postoperatively,there was no statistically significant difference in LVEF level between the two groups(P>0.05).1 month postoperatively,LVEF of(54.43±5.31)%in the experimental group was higher than that of(52.33±6.66)%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of MACEs and bleeding events between the two groups(P>0.05).The length of hospital stay of(7.30±3.44)d in the experimental group was shorter than that of(8.72±4.46)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Intracoronary injection of recombinant human prourokinase for injection during PPCI can improve short-term cardiac function of patients

关 键 词：注射用重组人尿激酶原 急性心肌梗死 直接经皮冠状动脉介入术 冠状动脉溶栓 

分 类 号：R542.22[医药卫生—心血管疾病]