莫西沙星联合小剂量激素对高龄重症呼吸机肺炎患者的疗效分析  

Efficacy analysis of moxifloxacin combined with low-dose hormone in elderly patients with severe ventilator-associated pneumonia

作　　者：于璐 YU Lu(Liaoning Health Industry Group Fuxin Mine General Hospital,Fuxin 123000,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院,123000

出　　处：《中国现代药物应用》2023年第17期122-125,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析莫西沙星联合小剂量激素对高龄重症呼吸机肺炎患者的治疗效果。方法66例高龄重症呼吸机肺炎患者,按照治疗方式的不同分为对照组和研究组,每组33例。两组患者均接受常规给氧、雾化等治疗,对照组患者在常规治疗基础上给予小剂量激素治疗,研究组患者在对照组基础上给予莫西沙星治疗。比较两组患者临床疗效、临床症状消失时间及治疗前后炎症指标[血清降钙素原(PCT)、白细胞计数(WBC)和C反应蛋白(CRP)]变化情况。结果研究组患者治疗显效12例,有效18例,无效3例,治疗总有效率为90.91%;对照组患者治疗显效9例,有效14例,无效10例,治疗总有效率为69.70%。研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者PCT、WBC、CRP水平均低于本组治疗前,且研究组患者PCT、WBC、CRP水平分别为(0.72±0.08)ng/ml、(7.08±1.02)×10^(9)/L、(30.28±3.47)mg/L,低于对照组的(1.33±0.16)ng/ml、(9.11±1.24)×10^(9)/L、(45.26±5.04)mg/L,差异有统计学意义(P<0.05)。研究组患者啰音、咳嗽、发热消失时间分别为(3.27±0.47)、(5.37±0.63)、(6.68±0.83)d,均短于对照组的(5.01±0.71)、(7.27±0.82)、(7.76±0.92)d,差异有统计学意义(P<0.05)。结论高龄重症呼吸机肺炎患者接受莫西沙星联合小剂量激素治疗效果较好,可以明显改善炎症反应,缩短消炎时间和临床症状消失时间。Objective To analyze the therapeutic effect of moxifloxacin combined with low-dose hormone in elderly patients with severe ventilator-associated pneumonia.Methods A total of 66 elderly patients with severe ventilator-associated pneumonia were divided into control group and study group according to different treatment methods,with 33 cases in each group.Patients in both groups received conventional administration of oxygen and nebulization.On this basis,the control group was treated with low-dose hormone therapy,and the study group was treated with moxifloxacin on the basis of control group.Both groups were compared in terms of clinical efficacy,disappearance time of clinical symptoms and the changes of inflammation indexes[procalcitonin(PCT),white blood cell count(WBC)and C-reactive protein(CRP)]before and after treatment.Results In the study group,12 cases were significantly effective,18 cases were effective,3 cases were ineffective,and the total effective rate was 90.91%;in the control group,9 cases were significantly effective,14 cases were effective,10 cases were ineffective,and the total effective rate was 69.70%.The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,PCT,WBC and CRP levels in both groups were lower than those before treatment in this group;the levels of PCT,WBC and CRP in the study group were(0.72±0.08)ng/ml,(7.08±1.02)×10^(9)/L and(30.28±3.47)mg/L,which were lower than those of(1.33±0.16)ng/ml,(9.11±1.24)×10^(9)/L and(45.26±5.04)mg/L in the control group;the differences were statistically significant(P<0.05).The disappearance time of rale,cough and fever in the study group were(3.27±0.47),(5.37±0.63)and(6.68±0.83)d,which were shorter than those of(5.01±0.71),(7.27±0.82)and(7.76±0.92)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Moxifloxacin combined with low-dose hormone has significant effect on elderly patients with severe ven

关 键 词：莫西沙星 小剂量激素 重症呼吸机肺炎 治疗效果 高龄 

分 类 号：R563.1[医药卫生—呼吸系统]