远志-石菖蒲药对异病同治抑郁症和阿尔茨海默病的网络药理学研究  

Study on network pharmacology of Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair for depression and Alzheimer disease with the same treatment

作　　者：贾谭蓉 王佳佳[1] 王星[1] 刘俊岑 巴寅颖[1] Jia Tanrong;Wang Jiajia;Wang Xing;Liu Juncen;Ba Yinying(School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《国际中医中药杂志》2023年第9期1144-1150,共7页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81703670);首都医科大学科研培育基金项目(PYZ21028)。

摘　　要：目的运用网络药理学技术,从分子水平探讨远志-石菖蒲药对异病同治抑郁症和AD的作用机制。方法检索TCMSP、TCMID、ETCM数据库并结合文献分析,获得远志-石菖蒲药对的有效成分;检索GeneCards、TTD、CTD数据库获得抑郁症和AD疾病靶点,通过SwissTargetPrediction平台预测药对有效成分的作用靶点,获得药对与疾病的交集靶点;采用Cytoscape 3.6.1构建远志-石菖蒲药对"成分-共有靶点-疾病"相互作用网络,借助Metascape平台进行GO功能与KEGG通路富集分析,并进行分子对接验证。结果通过检索数据库与文献分析,获得远志-石菖蒲药对78个有效成分,对应41个异病同治靶点,GO功能主要富集于对脂多糖的反应、细胞对氮化合物的反应,KEGG通路主要富集于脂质与动脉粥样硬化、钙信号通路、5-羟色胺能突触和胰岛素抵抗等,核心靶点为PTGS2、ESR2等。分子对接显示,大部分核心成分与核心靶点可形成稳定构象。结论远志-石菖蒲药对异病同治具有多成分、多靶点、多途径的特点,可通过远志皂苷元、1-carbobutoxy-β-carboline、6-hydroxy-1,2,3,7-tetramethoxyxanthone、山柰酚等核心成分,作用于PTGS2等靶点,调控脂质与动脉粥样硬化、钙信号通路、5-羟色胺能突触和胰岛素抵抗通路,发挥异病同治抑郁症和AD的作用。Objective To explore the molecular mechanism of Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair for depression and Alzheimer disease(AD)with the same treatment through network pharmacology.Methods Effective components of Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair were retrieved from TCMSP,TCMID and ETCM databases.The disease targets of depression and AD were retrieved from GeneCards,TTD and CTD databases.Targets of action of drugs on active components were predicted through SwissTargetPrediction,and then the intersection targets of medicinal pair and the diseases were taken.Cytoscape 3.6.1 was used to construct the interaction network of Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair on"component-common target-disease".The enrichment analysis of GO function and KEGG pathway was carried out with the help of Metascape platform,and molecular docking verification was carried out.Results Through searching the databases and literature,78 compounds in Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair were obtained,corresponding to 41 targets of different diseases with the same treatment.The GO function was mainly concentrated in response to lipopolysaccharide and cellular response to nitrogen compound.The KEGG pathway was mainly concentrated in lipid and atherosclerosis,calcium signaling pathway,serotonergic synapse,insulin resistance and so on.The core targets were PTGS2,ESR2,etc.Molecular docking showed that most of the core components could form stable conformation with the core targets.Conclusions Polygalae Radix-Acori Tatarinowii Rhizoma medicinal pair has the characteristics of multi-component,multi-target and multi-pathway in the same treatment of depression and AD.Through their core components of senegenin,1-carbobutoxy-β-carboline,6-hydroxy-1,2,3,7-tetramethoxyxanthone,kaempferol and etc.,the pair can act on PTGS2 and other targets,regulate lipid and atherosclerosis,calcium signaling pathway,serotonergic synapse,insulin resistance and so on,and play a therapeutic role in

关 键 词：远志 石菖蒲 抑郁症 阿尔茨海默病 网络药理学 异病同治 

分 类 号：R285[医药卫生—中药学]