HIF-1α调控的巨噬细胞极化在免疫相关疾病中作用的研究进展  

Research progress on the role of HIF-1α-regulated macrophage polarization in immune related disease

作　　者：唐梦燕 闫东梅[1] Tang Mengyan;Yan Dongmei(Department of Immunology,School of Basic Medicine,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学基础医学院免疫学系,长春130021

出　　处：《国际免疫学杂志》2023年第5期524-528,共5页International Journal of Immunology

基　　金：国家自然科学基金(81871245);吉林省科技厅项目(20210509009RQ);吉林省教育厅项目(JJKH20221057KJ)。

摘　　要：缺氧诱导因子1α(hypoxia-inducible factor-1α,HIF-1α)在巨噬细胞极化的过程中必不可少,是将糖代谢活动与免疫联系起来的枢纽。文章就HIF-1α调控的巨噬细胞极化及其在细菌感染性疾病、肿瘤、自身免疫病和动脉粥样硬化等疾病中作用进行综述,期望以HIF-1α调控的巨噬细胞极化为主要靶标,为疾病的发生机制及临床治疗提供新的思路。Hypoxia-inducible factor-1α(HIF-1α)is essential in the process of macrophage polarization,serving as a hub linking glucose metabolic activity to immunity.This review summarizes the research progress of HIF-1α-regulated macrophage polarization and its role in tumors,autoimmune diseases,atherosclerosis and other diseases.It is expected that HIF-1α-regulated macrophage polarization will be the main target,and provide new ideas for the mechanism and clinical treatment of diseases.

关 键 词：缺氧诱导因子1Α 巨噬细胞 极化 免疫相关疾病 

分 类 号：R593[医药卫生—内科学]