糖皮质激素副作用所致SLE器官损害中线粒体机制研究进展  

Research progress on mitochondrial mechanism of SLE organ damage caused by glucocorticoid side effects

作　　者：黄彩凤 程喜平[1,2,3] 赵晓庆 黄杏兰 Huang Caifeng;Cheng Xiping;Zhao Xiaoqing;Huang Xinglan(Department of Dermatology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;State Key Laboratory of Respiratory Disease,Guangzhou 510120,China;Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization,Guangzhou 510080,China;Department of TCM The Affiliated TCM Hospital of Guang Zhou Medical University,Guangzhou 510120,China;Department of Dermatology,Guangzhou Twelfth People’s Hospital,Guangzhou 510630,China)

机构地区：[1]广州医科大学附属第一医院皮肤科,广州510120 [2]呼吸疾病国家重点实验室,广州510120 [3]广东省中医药信息化重点实验室,广州510080 [4]广州医科大学附属中医医院中医科,广州510120 [5]广州市第十二人民医院皮肤科,广州510630

出　　处：《国际免疫学杂志》2023年第4期433-438,共6页International Journal of Immunology

基　　金：国家自然科学基金(81673983,82074172);广东省钟南山医学基金(ZNSA-2020013);广东省中医药信息化重点实验室开放基金(2022102)。

摘　　要：糖皮质激素(glucocorticoid,GC)是公认的治疗系统性红斑狼疮(systemic lupus erythematosus,SLE)的基础药物。但最新研究显示GC副作用可以引起器官损害,其机制不明。GC在细胞质和GC受体结合后,除了转运至细胞核也转运至线粒体,GC通过细胞核通路的基因调控,发挥抗炎功能,目前研究显示GC线粒体途径调控具有促炎作用,与GC治疗红斑狼疮相关器官损害发生机制有契合点。GC既可以抗炎缓解SLE器官损害,也可以慢性蓄积性损害SLE器官,GC对SLE器官损害是双刃剑,且机制不清,文章对相关研究进行综述。Glucocorticoid(GC)is recognized as the basic drug for the treatment of systemic lupus erythematosus(SLE).However,the latest research shows that the side effects of GC can cause organ damage,and its mechanism is unknown.After the combination of cytoplasm and GC receptor,GC is not only transported to nucleus,but also to mitochondria.GC plays an anti-inflammatory role through gene regulation of nuclear pathway.Current research shows that the regulation of GC mitochondrial pathway has a pro-inflammatory effect,which is consistent with the mechanism of GC in the treatment of lupus erythematosus related organ damage.Although GC can alleviate SLE organ damage by preventing inflammation,GC will cause cumulative chronic damage to SLE organs.Therefore,GC is a double-edged sword for SLE organ damage,and the mechanism is unclear.This paper reviews the relevant research.

关 键 词：糖皮质激素 系统性红斑狼疮 器官损害 线粒体 

分 类 号：R593.241[医药卫生—内科学]