磷丙泊酚二钠与丙泊酚中/长链脂肪乳用于全身麻醉诱导脑电双频指数值对比观察  

Comparative study on bispectral index value induced by fospropofol disodium and propofol medium/long chain fat emulsion in general anesthesia induction

作　　者：谭丹丹 朱宇航 刘德行 覃涵睿 朱昭琼 Tan Dandan;Zhu Yuhang;Liu Dexing;Qin Hanrui;Zhu Zhaoqiong(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院麻醉科,遵义563000

出　　处：《中华实验外科杂志》2023年第8期1611-1614,共4页Chinese Journal of Experimental Surgery

摘　　要：目的分析20 mg/kg磷丙泊酚二钠用于全身麻醉诱导时脑电双频指数(BIS)值稳定性。方法采用随机、双盲双模拟、阳性对照研究方法, 将全身麻醉下行择期手术的受试者179例按1:2随机分为对照组60例(2 mg/kg丙泊酚)和试验组119例(20 mg/kg磷丙泊酚二钠)。观察并记录麻醉过程中BIS值的变化, 麻醉诱导成功率(5 min内MOAA/S≤1)、安全性指标、不良反应发生率等。结果 173例患者完成了本研究, 其中对照组58例、试验组115例。试验组在插管即刻、切皮即刻BIS值均低于对照组(32.76±9.15比39.28±10.09、40.05±12.17比48.62±10.35, P<0.05), 但两组在相应节点的变化差异无统计学意义(P>0.05), 在出手术室时两组BIS值均回升至基线水平(P>0.05)。试验组与对照组麻醉诱导成功率差异无统计学意义(97.4%比96.6%, P>0.05);两组血压在插管及切皮即刻低于基线值, 苏醒期恢复到基线水平, 血压变化趋势一致。在给药即刻两组患者心率稍增快, 手术开始后逐渐减慢低于基线值水平, 苏醒期恢复到基线值水平。试验组常见不良反应为感觉异常(81.74%)、收缩压(SBP)降低(26.09%)及脉搏血氧饱和度(SpO2)下降(23.48%), 均呈一过性。结论磷丙泊酚二钠与丙泊酚中/长链脂肪乳均能满足气管插管所需麻醉深度, 安全有效, 且不影响患者术后苏醒。Objective To analyze the stability of bispectral index(BIS)value induced by 20 mg/kg fospropofol disodium in general anesthesia.Methods In a randomized,double-blind,double simulation,positive control study,179 subjects undergoing elective surgery under general anesthesia were randomly divided into a control group of 60 cases(2 mg/kg propofol)and a test group of 119 cases(20 mg/kg fospropofol disodium)according to 1:2.During the induction period of general anesthesia,patients were injected with 2 mg/kg propofol and 20 mg/kg fospropofol disodium.The changes of bispectral index(BIS)during anesthesia,the success rate of induction(MOAA/S≤1 within 5 min),vital signs and the incidence of adverse reactions were observed and recorded.Statistical analysis was conducted using SPSS 18.0 software.Results A total of 173 patients completed the study,including 58 in the control group and 115 in the experimental group.The BIS in the experimental group was lower than that in the control group at the time of intubation and skin incision(32.76±9.15 vs.39.28±10.09,40.05±12.17 vs.48.62±10.35,P<0.05),but there was no statistically significant difference between the two groups at these two time points(P>0.05),and the BIS in both groups rose to the baseline level when they left the operating room(P>0.05).The success rate of induction in the two groups were similar(97.4%vs.96.6%,P>0.05).The blood pressure of the two groups was lower than the baseline value immediately after intubation and skin incision,and returned to the baseline level during the awakening period,and the blood pressure changed in the same trend.The heart rate of patients in the two groups increased slightly immediately after administration,gradually slowed down below the baseline level after the operation began,and returned to the baseline level during the recovery period.The relatively common adverse reactions in the experimental group were paresthesia(81.74%),decreased SBP(26.09%)and decreased SpO2(23.48%),all of which were temporary.Conclusion Fospropofol and pr

关 键 词：磷丙泊酚二钠 丙泊酚 全身麻醉诱导 脑电双频指数 不良反应 

分 类 号：R614[医药卫生—麻醉学]