eATP-P2X受体介导针刺镇痛作用机制的研究进展  

Research progress on mechanism of acupuncture analgesic mediated by eATP-P2X receptor

作　　者：任善洁 伊晓倩 苏帆[2] Ren Shanjie;Yi Xiaoqian;Su Fan(Department of Anesthesiology,Jinan Third People's Hospital,Jinan City,Shandong Province 250132,China;Department of Anesthesiology,Affiliated Hospital of Shandong University of Chinese Medicine,Jinan City,Shandong Province 250011,China)

机构地区：[1]济南市第三人民医院麻醉科,济南市250132 [2]山东中医药大学附属医院麻醉科,济南市250011

出　　处：《中华疼痛学杂志》2023年第4期669-672,共4页Chinese Journal Of Painology

摘　　要：细胞外三磷酸腺苷(eATP)作为神经递质与P2X受体结合激活离子通道,对痛觉的产生和维持都发挥着重要作用。eATP-P2X受体广泛存在于神经、免疫、平滑肌、心肌、血液及各种腺体细胞中。针刺是一种行之有效的镇痛方法,其穴位信号传导、中枢痛觉调控及效区调节与保护均有eATP-P2X受体的参与。As a neurotransmitter binding to P2X receptor activates ion channels,extracellular adenosine triphosphate(eATP)plays an important role in the production and maintenance of pain sensation.eATP-P2X receptor exists widely in nerve,immune,smooth muscle,myocardium,blood and various glandular cells.Acupuncture is an effective analgesic method,in which the eATP-P2X receptor is involved in acupoint signal transduction,central pain regulation and effector regulation and protection.

关 键 词：针灸疗法 镇痛 P2X受体 

分 类 号：R614[医药卫生—麻醉学]