口腔癌筛查与诊断的影像学技术及发展趋势  

Imaging Technologies for Oral Cancer Screening and Diagnosis and Their Development Trends

作　　者：梁艳梅[1] 杨子晗 尚建伟[2] 刘晨路 张军[4] Liang Yanmei;Yang Zihan;Shang Jianwei;Liu Chenlu;Zhang Jun(Institute of Modern Optics,Nankai University,Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology,Tianjin 300350,China;Department of Oral Pathology,Tianjin Stomatological Hospital,Department of Oral Pathology,Hospital of Stomatology,Nankai University,Tianjin 300041,China;Department of Oral Medicine,Tianjin Stomatological Hospital,Department of Oral Medicine,Hospital of Stomatology,Nankai University,Tianjin 300041,China;Department of Oral-Maxillofacial Surgery,Tianjin Stomatological Hospital,Department of Oral-Maxillofacial Surgery,Hospital of Stomatology Nankai University,Tianjin 300041,China)

机构地区：[1]南开大学现代光学研究所,天津市微尺度光学信息技术科学重点实验室,天津300350 [2]天津市口腔医院病理科,南开大学附属口腔医院病理科,天津300041 [3]天津市口腔医院口腔黏膜病科,南开大学附属口腔医院口腔黏膜病科,天津300041 [4]天津市口腔医院口腔颌面外科,南开大学附属口腔医院口腔颌面外科,天津300041

出　　处：《中国激光》2023年第15期1-13,共13页Chinese Journal of Lasers

基　　金：国家自然科学基金(61875092);京津冀基础研究合作专项项目(19JCZDJC65300);天津市科技支撑重点项目(17YFZCSY00740)。

摘　　要：目前,口腔黏膜病的筛查和诊断主要依靠临床医生的目视观察和触诊,组织病理学仍然是口腔癌诊断的金标准.目视观察、触诊和组织病理学方法都存在不同的局限性.近年来,随着影像学技术的不断发展,X射线计算层析、核磁共振、超声、荧光、光声、光学相干层析等技术逐渐被应用于口腔黏膜病的成像研究.不同影像学技术的成像原理、成像能力及性能各不相同,在口腔癌的筛查与诊断中可以发挥不同的优势,具有极大的临床应用潜力.本文主要总结了现有影像学技术在辅助口腔癌筛查和诊断中的研究进展,分析了它们的临床适用性,并预测了口腔癌筛查与诊断影像学技术未来的发展趋势.Significance Oral cancer is among the most common cancers of the head and neck.Despite advancements in targeted cancer therapy,the survival rates of oral cancer patients have plateaued over the last 50 years.Common screening methods for oral lesions,such as visual inspection and palpation of tissue surfaces,are highly dependent on the experience of clinicians.Even if the biopsy or histopathological examination is performed for highly suspicious tissue regions,the limitations of time-consuming,invasive,and labelintensive are still inevitable.In clinical practice,intraoperative frozen section biopsies for surgical margins are routine procedures performed after en bloc resections of oral cancers.However,surgical margins are usually selected according to surgeon estimates of sites that may be suspicious of inadequate resection,resulting in the omission of positive margins.In addition,early detection of oral cancer plays a critical role in improving the prognosis and survival rate,but,accurate identification is difficult based on conventional screening methods.To improve the clinical diagnosis of oral diseases,researchers have conducted numerous studies on auxiliary diagnostic techniques,including X-ray computed tomography(X-CT),magnetic resonance imaging(MRI),ultrasound imaging(UI),fluorescence imaging(FI),photoacoustic imaging(PAI),and optical coherence tomography(OCT).Based on the associated imaging theories,different imaging technologies have unique advantages in terms of detecting oral diseases,resulting in different application scenarios.In this paper,we review the research on the foregoing auxiliary imaging technologies,summarize their advantages and disadvantages,and discuss the challenges and future developments in oral clinical applications.Progress Different technologies demonstrate different features in terms of improving diagnostic sensitivity,specificity,resolution,and so on.Notably,X-CT and MRI are the earliest techniques used in oral clinics.They are exceptional in terms of their imaging depth and can

关 键 词：医用光学 医学和生物成像 口腔癌 影像学技术 筛查 诊断 

分 类 号：TN247[电子电信—物理电子学]