基于可视中国人蒙特卡罗分析实现肺部无创光学监测的探讨  

Noninvasive Optical Monitoring of Lung Based on Monte Carlo Analysis of Visual Chinese Human

作　　者：杨松齐 郭江辉 李婷 Yang Songqi;Guo Jianghui;Li Ting(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China;School of Optoelectronic Science and Engineering,University of Electronic Science&Technology of China,Chengdu 611731,Sichuan,China)

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津300192 [2]电子科技大学光电科学与工程学院,四川成都611731

出　　处：《中国激光》2023年第15期121-130,共10页Chinese Journal of Lasers

基　　金：国家自然科学基金面上项目(81971660);天津杰出青年基金(20JCJQIC00230);四川国际科技合作重点项目(2021YFH0004);中国医学科学院健康创新工程系列项目(2021-I2M-1-042,2021-I2M-1-058,2022-I2M-C&T-A-00,2022-I2MC&T-B-012)。

摘　　要：肺部疾病的诊断和治疗很重要,目前实现肺部疾病的无创监测具有一定困难.笔者采用近红外光子传输技术,定量研究了人体肺部的结构.以可视中国人数据集(VCH)为实验对象,利用蒙特卡罗(MC)模拟对其进行了仿真.对肺部血流动力学非侵入式测量的可行性进行了理论探讨,并对光子在肺部传输时的最佳光源位置进行了研究,同时还对光源-检测器距离进行了优化.光通量强度显示,光子在人体肺部可以穿透6~8.4mm,光源到检测器的最佳距离是2.8~3.6 cm.在此基础上,对13名志愿者进行了近红外漫反射实验,实验数据与仿真结果基本一致.实验结果表明,本研究在肺部血流动力学无创监测方面具有广阔的应用前景,同时也为生物医学光学技术在人体上的应用提供了参考.Objective Lung disease is a local or systemic disease characterized by pulmonary manifestations.The importance of this organ,the lung,to the human body cannot be overstated,and a diseased or damaged lung can seriously affect human health.According to the World Health Organization,global cancer incidence and mortality rates have shown a continuous increase in recent years,with lung cancer topping the list.With increasing air pollution,a growing smoking and aging population,and the emergence of drug-resistant pathogens,tuberculosis and pneumoconiosis have become the top two infectious diseases in China,accounting for 90%of occupational disease cases.The diagnosis and treatment of lung diseases are becoming increasingly important,and many patients with lung diseases such as lung cancer,severe pneumonia,emphysema,and pulmonary embolism in intensive care units require noninvasive,continuous,and immediate monitoring.Thus,noninvasive real-time lung monitoring methods are important for the prevention and treatment of lung diseases.Methods The VCH slice specimens used in this study were from an adult male that was sliced horizontally at regular intervals in a standing position.Each slice was a digital color photograph with distinguishable tissues.The lung was divided into five lobe regions for simulations.Two hundred such images were combined with image processing methods to construct a three-dimensional matrix to present the entire lung tissue structure.According to the location of the lung lobes,five lung lobe models of 420 voxel×436 voxel×200 voxel were segmented.The simulation results showed the specific situation of the five lung lobes.Each voxel was a 0.04 cm×0.04 cm×0.04 cm cube.The Monte Carlo method was used to simulate the migration of light in the lungs.This study used the MCVM software,which targets 3D voxelized media.In the simulation,the light source was set to an 800 nm point light source,and the optical properties of 10 tissues were in the near-infrared band at 800 nm.The light source was initially loc

关 键 词：医用光学 近红外光谱技术 蒙特卡罗模拟 无创检测 肺部监测 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]