有机聚合物点及生物光学应用  

Organic Polymer Dots and Their Bio⁃Optical Applications

作　　者：邓思乐 陈昊彬 Deng Sile;Chen Haobin(Department of Biomedical Engineering,School of Basic Medical Sciences,Central South University,Changsha 410013,Hunan,China)

机构地区：[1]中南大学基础医学院生物医学工程系,湖南长沙410013

出　　处：《中国激光》2023年第15期202-228,共27页Chinese Journal of Lasers

基　　金：国家自然科学基金(82202296);中南大学引进人才科研启动项目(202045009)。

摘　　要：近年来,有机半导体聚合物点(Pdots)以其光吸收截面大、稳定性好、生物相容性好、光物理性质可调等特性受到了广泛关注.聚合物点已被应用于生物传感、生物成像以及光学治疗等生物光学应用领域,对即时检测、活体成像、肿瘤治疗等具有重要意义.本文简要介绍了聚合物点的发光原理、制备方法、性能表征和修饰策略,总结了聚合物点在生物传感、生物成像以及光治疗应用中的最新研究进展,并分析了聚合物点在生物光学领域面临的挑战及未来的发展方向.Significance In recent years,there has been significant progress in the development and application of nanomaterials in the field of biooptics.These advancements have led to benefits for medical diagnosis and treatment,such as biosensing,bioimaging,cell tracking,and phototherapy.Nanomaterials possess unique properties that allow for advances in targeting,precision,resolution,realtime and noninvasive detection for biooptical applications.Among a large number of luminescent nanomaterials,organic semiconducting polymer dots(Pdots)have attracted extensive attention due to their large absorption cross sections,high brightness,stable photostability,excellent biocompatibility,and tunable spectra.Compared to traditional luminescent dyes,which have weak photostability,low brightness,and short lifetime,Pdots have smaller sizes and higher photophysical properties,which contribute to better conversion efficiency and detection results.Pdots have been widely used in the biooptical field,including in biosensing,bioimaging,and phototherapy applications,which are of great significance for pointofcare testing,in vivo imaging,and tumor therapy.Pointofcare testing based on biosensing technology enables the specific and rapid detection of analytes,which contain significant physiological information.This promotes patient selfmanagement of health.The outstanding sensitivity,response time,selectivity,and reversibility of Pdots make it possible to ensure the convenience and speed of detection while maintaining the same accuracy as laboratory testing.Apart from biosensing,bioimaging technology realizes the visualization of internal structure of organisms and achieves functional imaging for significant medical signals,offering accurate and reliable information for disease diagnosis and treatment.Pdots used as optical probes usually provide nearinfrared imaging,which has deeper penetration and lower background interference compared to conventional contrast agents.More importantly,the excellent specificity and tumor targeting capabilities of

关 键 词：生物光学 生物传感 生物成像 光学治疗 有机半导体 聚合物点 

分 类 号：R318[医药卫生—生物医学工程]