基于金属有机框架的纳米酶及医学应用进展  

Nanozymes Based on Metal-organic Frameworks and Its Progress in Medical Application

作　　者：任安俊 徐靖 罗伦[2] 郁玉发 张琼瑶 REN An-jun;XU Jing;LUO Lun;YU Yu-fa;ZHANG Qiong-yao(School of Pharmaceutical Sciences,Hubei University of Medicine,Shiyan Hubei 442000,China;Hubei key Laboratory of Wudang Characteristic Chinese Medicine Research,Hubei University of Medicine,Shiyan Hubei 442000,China)

机构地区：[1]湖北医药学院药学院,湖北十堰442000 [2]湖北医药学院武当特色中药研究湖北省重点实验室,湖北十堰442000

出　　处：《当代化工》2023年第8期1954-1961,共8页Contemporary Chemical Industry

基　　金：湖北省卫计委科研项目(项目编号:WJ2017M215);十堰市科技局引导性科研项目(项目编号:19Y20)。

摘　　要：纳米酶因其成本低、稳定性高、催化效率高、易储存等而被广泛关注。金属有机骨架(MOFs)作为纳米酶的重要分支,其超高的比表面积、孔道结构可调、丰富的骨架构造和良好的生物相容性等优良特征,使其成为模拟生物酶体系的理想材料。介绍了基于MOFs的类氧化酶、类过氧化物酶、类过氧化氢酶、类超氧化物歧化酶及多酶活性系统,并对其在医学方面的应用进行了总结。最后,讨论了基于MOFs纳米酶目前面临的挑战及未来的应用前景。Nanozyme has attracted wide attention because of its low cost,high stability,high catalytic efficiency,easy storage and so on.As an important branch of nanozyme,metal-organic frameworks(MOFs)has some excellent characteristics,such as ultra-high specific surface area,adjustable pore structure,rich skeleton structure and good biocompatibility,which makes it become an ideal material to simulate biological enzyme system.In this paper,the oxidase-like,peroxidase-like,catalase-like,superoxide dismutase-like and multi-enzyme activity systems based on MOFswere introduced,and their applications in medicinewere summarized.Finally,the current challenges and future application prospects of MOFs-based nanozymes were discussed.

关 键 词：纳米酶 金属有机框架 医学应用 

分 类 号：TQ050.4[化学工程]