茯苓三萜生物合成过程调控研究进展  

Research progress in process regulation of poria triterpenes biosynthesis

作　　者：邓丹 刘媛 唐泽群 占慧慧 孟俊华 崔培梧[1,2,3] DENG Dan;LIU Yuan;TANG Zequn;ZHAN Huihui;MENG Junhua;CUI Peiwu(School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Research Lab of Traditional Chinese Medicine Property&Efficacy,Grade 3,National Administration of Traditional Chinese Medicine,Changsha 410208,China;Mycomedicine Research Lab,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]国家中医药管理局中药药性与药效三级科研实验室,长沙410208 [3]湖南中医药大学菌物药研究室,长沙410208

出　　处：《中华中医药杂志》2023年第9期4278-4285,共8页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药科研计划项目[No.D2022139(A2022005-17)];湖南省大学生创新创业训练计划项目(No.湘教通[2020]191号-2608,No.湘教通[2022]174号-2918);湖南中医药大学研究生创新课题(No.校行研字[2021]20号-50,No.校行研字[2022]20号-87);湖南中医药大学中药炮制传承基地开放基金项目(No.2022ZYPZ07);湖南中医药大学生物工程重点学科(No.校行科字[2018]3号)

摘　　要：茯苓三萜是茯苓的重要活性成分,具有抑菌、抗炎、抗肿瘤等功效,但其在茯苓菌核中含量极低,限制了茯苓三萜的开发应用。伴随着医药、食品行业对茯苓资源需求的持续增长与茯苓栽培过程对松材过度消耗、栽培周期长等矛盾的日益突出,探索茯苓三萜生物合成的过程调控将对缓解茯苓资源供需矛盾具有重要意义。因此,文章围绕茯苓三萜的结构、生物活性、生物合成途径及其过程调控等进行综述,进而探讨强化茯苓三萜生物合成过程的调控策略,以期为实现茯苓三萜的高效合成提供参考。Poria triterpenes are important active ingredients in Poria,which exhibite significant antibacterial,antiinflammatory and antitumor effects.However,the content of poria triterpenoids in the sclerotium of Poria is extremely low,which has strictly limited the development and application of poria triterpenes.Along with the increasing demand for Poria resources in pharmaceutical industry,as well as the excessive consumption of pine resources required for Poria cultivation,exploring the regulation strategies for improving poria triterpenes productivity is a very promising way and will supply an important reference for Poria exhausting industries.Thus,the structure,bioactivity,biosynthesis pathway and process regulation of poria triterpenes were reviewed in this paper,and the strategies referred to enhance poria triterpenes productivity were also discussed.This review will provide an important reference for fulfilling high productivity of poria triterpenes through green biosynthetic process.

关 键 词：茯苓三萜 生物合成 甲羟戊酸途径 氧化鲨烯环化酶 细胞色素P450 代谢调控 茯苓 研究进展 

分 类 号：S567.32[农业科学—中草药栽培] R284[农业科学—作物学]