海螵蛸在骨组织工程领域的研究进展  

Research progress of Sepiae Endoconcha in bone tissue engineering

作　　者：韦源青 郑飞 刘睿 王欣之[1,2,3] 吴皓 WEI Yuanqing;ZHENG Fei;LIU Rui;WANG Xinzhi;WU Hao(Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics,Nanjing 210023,China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]江苏省海洋药用生物资源研究与开发重点实验室,南京210023 [2]南京中医药大学,江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心,南京210023 [3]南京中医药大学药学院,南京210023

出　　处：《中华中医药杂志》2023年第9期4286-4290,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82204771);江苏省科技项目(No.BK20210695);江苏省高等学校基础科学项目(No.21KJA360007,No.21KJB360017);南京中医药大学中药学一流学科开放课题(No.2020YLXK009);南京中医药大学国家自然科学基金青年科学基金经费配套项目(No.XPT82204771)。

摘　　要：海螵蛸除传统功效外,现代研究认为其具有成骨作用,可作为骨组织工程材料应用,其主要成分为碳酸钙,同时含有蛋白、多肽、多糖、核苷、脂质和其他微量元素等。海螵蛸具有多孔结构,有一定耐压能力,亲水性强,作为骨支架材料表现出骨传导性、骨诱导性等促成骨活性以及促血管生成活性。文章系统归纳了海螵蛸组成、功效与骨工程材料之间的关系,对海螵蛸在骨修复材料研究上提出了建议。Sepiae Endoconcha is considered to have osteogenic effect in addition to its traditional functions and can be used as scaffold material of bone tissue engineering in modern studies.Its main component is calcium carbonate,and it also contains proteins,peptides,polysaccharides,nucleosides,lipids and other trace elements.Cuttlebone possesses porous structure,external pressure resistance and strong hydrophilicity.Thus,cuttlebone derived bone scaffold materials exhibit osteoconductive,osteoinductive and angiogenetic activity.This review provided a comprehensive analysis of the correlation between the composition,effectiveness of Sepiae Endoconcha and bone engineering materials.In addition,the medical material research direction of cuttlebone was proposed.

关 键 词：海螵蛸 乌贼骨 成骨 骨组织工程支架材料 物理性能 生物性能 骨组织工程 

分 类 号：R28[医药卫生—中药学]