同二聚体提升Aβ蛋白荧光探针性能  

Improving the Performance of Aβ Protein Fluorescent Probes by Homodimer

作　　者：苏豪 汪航行 SU Hao;WANG Hang-xing(College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062)

机构地区：[1]湖北大学化学化工学院,武汉430062

出　　处：《胶体与聚合物》2023年第3期115-117,121,共4页Chinese Journal of Colloid & Polymer

摘　　要：本研究根据经典的D-π-A结构设计了荧光探针M2,为进一步优化提高探针的对于β-淀粉样(Aβ)蛋白斑块的检测功能,本文利用端氨基烷基链将两个M2单体染料连接起来,形成同二聚体,增加对蛋白亲和力,并利用扭转分子内电荷转移(TICT),提高对蛋白响应性和信噪比。This research according to the classic D-π-A structure,designed the M2,fluorescent probe for further optimization to improve the probe for A beta protein detection.Here,two M2 monomer dyes were connected by terminal amino alkyl chain to form a homodimer to increase affinity for protein,and torsion intramolecular charge transfer(TICT)was used to improve responsiveness to protein and signal-to-noise ratio.

关 键 词：荧光探针 同二聚体 蛋白亲和力 Β-淀粉样蛋白 

分 类 号：O656[理学—分析化学]